Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 379033..379664 Replicon chromosome
Accession NZ_LR213455
Organism Shigella flexneri strain AUSMDU00008332 isolate AUSMDU00008332

Toxin (Protein)


Gene name hicA Uniprot ID A0A822PMR8
Locus tag E0E35_RS01845 Protein ID WP_001259384.1
Coordinates 379033..379308 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag E0E35_RS01850 Protein ID WP_000593555.1
Coordinates 379305..379664 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0E35_RS01830 (374051) 374051..375118 + 1068 WP_000361470.1 HlyD family secretion protein -
E0E35_RS01835 (375115) 375115..377850 + 2736 WP_000149170.1 ribosome-associated ATPase/putative transporter RbbA -
E0E35_RS01840 (377850) 377850..378974 + 1125 WP_001216257.1 ABC transporter permease -
E0E35_RS01845 (379033) 379033..379308 + 276 WP_001259384.1 type II toxin-antitoxin system HicA family toxin Toxin
E0E35_RS01850 (379305) 379305..379664 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
E0E35_RS01855 (379784) 379784..380185 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
E0E35_RS01860 (380191) 380191..380997 - 807 WP_000173660.1 nickel import ATP-binding protein NikE -
E0E35_RS01865 (380994) 380994..381758 - 765 WP_001136253.1 nickel import ATP-binding protein NikD -
E0E35_RS01870 (381758) 381758..382591 - 834 WP_001008973.1 nickel ABC transporter permease subunit NikC -
E0E35_RS01875 (382588) 382588..383532 - 945 WP_000947076.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 357852..379664 21812


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-81)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10146.89 Da        Isoelectric Point: 10.3748

>T288265 WP_001259384.1 NZ_LR213455:379033-379308 [Shigella flexneri]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
CDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT288265 WP_000593555.1 NZ_LR213455:379305-379664 [Shigella flexneri]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A822PMR8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References