Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 289451..290082 Replicon chromosome
Accession NZ_LR213452
Organism Shigella flexneri strain AUSMDU00008355 isolate AUSMDU00008355

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag E0E33_RS01410 Protein ID WP_025760846.1
Coordinates 289451..289726 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag E0E33_RS01415 Protein ID WP_000593555.1
Coordinates 289723..290082 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0E33_RS01395 284469..285536 + 1068 WP_000361470.1 HlyD family secretion protein -
E0E33_RS01400 285533..288268 + 2736 WP_000149172.1 ribosome-associated ATPase/putative transporter RbbA -
E0E33_RS01405 288268..289392 + 1125 WP_001216257.1 ABC transporter permease -
E0E33_RS01410 289451..289726 + 276 WP_025760846.1 type II toxin-antitoxin system HicA family toxin Toxin
E0E33_RS01415 289723..290082 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
E0E33_RS01420 290202..290603 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
E0E33_RS01425 290609..291415 - 807 WP_000173660.1 nickel import ATP-binding protein NikE -
E0E33_RS01430 291412..292176 - 765 WP_001136248.1 nickel import ATP-binding protein NikD -
E0E33_RS01435 292176..293009 - 834 WP_001008974.1 nickel ABC transporter permease subunit NikC -
E0E33_RS01440 293006..293950 - 945 WP_000947076.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 266960..290082 23122


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-81)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10145.95 Da        Isoelectric Point: 10.6469

>T288241 WP_025760846.1 NZ_LR213452:289451-289726 [Shigella flexneri]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKKGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
CDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT288241 WP_000593555.1 NZ_LR213452:289723-290082 [Shigella flexneri]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References