Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1235434..1236065 Replicon chromosome
Accession NZ_CP097840
Organism Shigella flexneri strain A

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag M9382_RS05825 Protein ID WP_025760846.1
Coordinates 1235434..1235709 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag M9382_RS05830 Protein ID WP_000593555.1
Coordinates 1235706..1236065 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9382_RS05810 (1230452) 1230452..1231519 + 1068 WP_000361470.1 HlyD family secretion protein -
M9382_RS05815 (1231516) 1231516..1234251 + 2736 WP_000149172.1 ribosome-associated ATPase/putative transporter RbbA -
M9382_RS05820 (1234251) 1234251..1235375 + 1125 WP_001216257.1 ABC transporter permease -
M9382_RS05825 (1235434) 1235434..1235709 + 276 WP_025760846.1 type II toxin-antitoxin system HicA family toxin Toxin
M9382_RS05830 (1235706) 1235706..1236065 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
M9382_RS05835 (1236185) 1236185..1236586 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
M9382_RS05840 (1236592) 1236592..1237398 - 807 WP_000173660.1 nickel import ATP-binding protein NikE -
M9382_RS05845 (1237395) 1237395..1238159 - 765 WP_001136248.1 nickel import ATP-binding protein NikD -
M9382_RS05850 (1238159) 1238159..1238992 - 834 WP_001008974.1 nickel ABC transporter permease subunit NikC -
M9382_RS05855 (1238989) 1238989..1239933 - 945 WP_000947076.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1214252..1236065 21813


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-81)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10145.95 Da        Isoelectric Point: 10.6469

>T246361 WP_025760846.1 NZ_CP097840:1235434-1235709 [Shigella flexneri]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKKGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
CDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT246361 WP_000593555.1 NZ_CP097840:1235706-1236065 [Shigella flexneri]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References