Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1236257..1236888 Replicon chromosome
Accession NZ_CP097831
Organism Shigella flexneri strain D

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag M9381_RS05845 Protein ID WP_025760846.1
Coordinates 1236257..1236532 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag M9381_RS05850 Protein ID WP_000593555.1
Coordinates 1236529..1236888 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9381_RS05830 (1231275) 1231275..1232342 + 1068 WP_000361470.1 HlyD family secretion protein -
M9381_RS05835 (1232339) 1232339..1235074 + 2736 WP_000149172.1 ribosome-associated ATPase/putative transporter RbbA -
M9381_RS05840 (1235074) 1235074..1236198 + 1125 WP_001216257.1 ABC transporter permease -
M9381_RS05845 (1236257) 1236257..1236532 + 276 WP_025760846.1 type II toxin-antitoxin system HicA family toxin Toxin
M9381_RS05850 (1236529) 1236529..1236888 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
M9381_RS05855 (1237008) 1237008..1237409 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
M9381_RS05860 (1237415) 1237415..1238221 - 807 WP_000173660.1 nickel import ATP-binding protein NikE -
M9381_RS05865 (1238218) 1238218..1238982 - 765 WP_001136248.1 nickel import ATP-binding protein NikD -
M9381_RS05870 (1238982) 1238982..1239815 - 834 WP_001008974.1 nickel ABC transporter permease subunit NikC -
M9381_RS05875 (1239812) 1239812..1240756 - 945 WP_000947076.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1215075..1236888 21813


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-81)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10145.95 Da        Isoelectric Point: 10.6469

>T246300 WP_025760846.1 NZ_CP097831:1236257-1236532 [Shigella flexneri]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKKGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
CDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT246300 WP_000593555.1 NZ_CP097831:1236529-1236888 [Shigella flexneri]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References