Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3303920..3304600 Replicon chromosome
Accession NC_013971
Organism Erwinia amylovora ATCC 49946

Toxin (Protein)


Gene name yeeV Uniprot ID D4HV69
Locus tag EAM_RS14795 Protein ID WP_004155189.1
Coordinates 3303920..3304240 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID D4HV68
Locus tag EAM_RS14800 Protein ID WP_004155188.1
Coordinates 3304277..3304600 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EAM_RS14775 (EAM_3015) 3301731..3301931 - 201 Protein_2882 transposase -
EAM_RS14780 (EAM_3017) 3302350..3302625 - 276 WP_004155192.1 type II toxin-antitoxin system RelE/ParE family toxin -
EAM_RS14785 (EAM_3018) 3302629..3302877 - 249 WP_004155191.1 ribbon-helix-helix domain-containing protein -
EAM_RS14790 (EAM_3019) 3302974..3303807 - 834 WP_004155190.1 DUF4942 domain-containing protein -
EAM_RS14795 (EAM_3020) 3303920..3304240 - 321 WP_004155189.1 TA system toxin CbtA family protein Toxin
EAM_RS14800 (EAM_3021) 3304277..3304600 - 324 WP_004155188.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EAM_RS14805 (EAM_3022) 3304613..3305083 - 471 WP_004155187.1 DNA repair protein RadC -
EAM_RS18595 (EAM_3023) 3305154..3305728 - 575 Protein_2889 DUF932 domain-containing protein -
EAM_RS18600 (EAM_3024) 3305953..3306195 - 243 WP_004155184.1 hypothetical protein -
EAM_RS14820 (EAM_3026) 3307405..3307602 + 198 WP_004155182.1 AlpA family phage regulatory protein -
EAM_RS19985 3307710..3308060 + 351 WP_004155181.1 hypothetical protein -
EAM_RS14830 (EAM_3028) 3308504..3309589 + 1086 WP_004155179.1 DNA sulfur modification protein DndB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3302629..3325491 22862
flank IS/Tn - - 3301707..3301931 224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(5-105)

Antitoxin

Antitoxin CbeA

(7-106)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12023.69 Da        Isoelectric Point: 5.4732

>T24692 WP_004155189.1 NC_013971:c3304240-3303920 [Erwinia amylovora ATCC 49946]
MHISTVPATVPVSSRLSPVQVWQQLLTYLLEHHYGLTLNDTPFHDDAAIEEHIDAGITLADAVNFLVERYELVRIDRKGF
TWQEQTPFLAATDILRARRATGLINI

Download         Length: 321 bp

>T24692 NC_013971:c3304240-3303920 [Erwinia amylovora ATCC 49946]
ATGCACATTTCAACTGTACCGGCCACGGTGCCGGTTTCGTCACGCCTGTCTCCCGTGCAGGTGTGGCAGCAACTTTTAAC
GTATCTGCTGGAGCATCATTACGGCTTGACACTAAATGACACGCCATTCCATGACGACGCGGCCATTGAGGAGCATATCG
ACGCAGGAATCACGCTCGCCGATGCTGTTAATTTTCTGGTGGAACGTTATGAACTGGTACGTATCGACCGCAAAGGATTT
ACATGGCAGGAGCAGACGCCATTCCTGGCCGCCACCGATATTCTCAGAGCAAGGCGAGCTACCGGATTAATAAATATTTA
A

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12088.81 Da        Isoelectric Point: 6.4689

>AT24692 WP_004155188.1 NC_013971:c3304600-3304277 [Erwinia amylovora ATCC 49946]
MSITLPHEWGLQSDITPRFGARLVQEGNRLYYLADRAGLTVSFSPIHLQKLDQAFPLFVEQLENMLRAGELNPHQQHQVT
IQLTSLTCIADTRGSCGYVYISIYPTP

Download         Length: 324 bp

>AT24692 NC_013971:c3304600-3304277 [Erwinia amylovora ATCC 49946]
ATGTCAATCACACTACCTCATGAATGGGGTCTACAAAGCGATATCACCCCACGATTTGGCGCGAGATTAGTTCAGGAAGG
CAATCGGCTGTATTACCTGGCTGACAGGGCTGGATTAACGGTGAGCTTTAGCCCGATACACCTGCAGAAACTGGATCAGG
CTTTCCCGCTGTTTGTAGAACAACTGGAAAATATGCTGCGTGCTGGCGAACTAAATCCACATCAGCAACATCAGGTGACC
ATTCAACTTACGAGTTTAACCTGTATAGCTGATACCCGTGGTAGCTGCGGTTACGTTTACATTTCTATTTATCCAACCCC
ATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A831EPU6

Antitoxin

Source ID Structure
AlphaFold DB A0A831ENV6

References