Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3119287..3119967 Replicon chromosome
Accession NZ_CP076594
Organism Erwinia amylovora isolate CP20086202

Toxin (Protein)


Gene name yeeV Uniprot ID D4HV69
Locus tag KQH36_RS14190 Protein ID WP_004155189.1
Coordinates 3119287..3119607 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID D4HV68
Locus tag KQH36_RS14195 Protein ID WP_004155188.1
Coordinates 3119644..3119967 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQH36_RS14170 (KQH36_14165) 3117098..3117298 - 201 Protein_2739 transposase -
KQH36_RS14175 (KQH36_14170) 3117717..3117992 - 276 WP_004155192.1 type II toxin-antitoxin system RelE/ParE family toxin -
KQH36_RS14180 (KQH36_14175) 3117996..3118244 - 249 WP_004155191.1 ribbon-helix-helix domain-containing protein -
KQH36_RS14185 (KQH36_14180) 3118341..3119174 - 834 WP_004155190.1 DUF4942 domain-containing protein -
KQH36_RS14190 (KQH36_14185) 3119287..3119607 - 321 WP_004155189.1 TA system toxin CbtA family protein Toxin
KQH36_RS14195 (KQH36_14190) 3119644..3119967 - 324 WP_004155188.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KQH36_RS14200 (KQH36_14195) 3119980..3120450 - 471 WP_004155187.1 DNA repair protein RadC -
KQH36_RS14205 (KQH36_14200) 3120521..3121095 - 575 Protein_2746 DUF932 domain-containing protein -
KQH36_RS14210 (KQH36_14205) 3121320..3121562 - 243 WP_004155184.1 hypothetical protein -
KQH36_RS14215 (KQH36_14210) 3122772..3122969 + 198 WP_004155182.1 AlpA family phage regulatory protein -
KQH36_RS14220 3123077..3123427 + 351 WP_004155181.1 hypothetical protein -
KQH36_RS14225 (KQH36_14220) 3123871..3124956 + 1086 WP_004155179.1 DNA sulfur modification protein DndB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3117326..3140888 23562
flank IS/Tn - - 3117074..3117298 224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(5-105)

Antitoxin

Antitoxin CbeA

(7-106)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12023.69 Da        Isoelectric Point: 5.4732

>T206011 WP_004155189.1 NZ_CP076594:c3119607-3119287 [Erwinia amylovora]
MHISTVPATVPVSSRLSPVQVWQQLLTYLLEHHYGLTLNDTPFHDDAAIEEHIDAGITLADAVNFLVERYELVRIDRKGF
TWQEQTPFLAATDILRARRATGLINI

Download         Length: 321 bp

>T206011 NZ_CP102065:1709974-1710318 [Enterococcus faecalis]
ATGAAAAGTATCAAAGAGTTGGTGGAAGAATATGAAGTAGAGTTAGTTTTTGCTCCAATAAATAAGCGCGCATGTTACGA
GCCAAGTGAAAGGATAATTTTCGTTAATCAAAATTTATCTATCGAAGAACAAGAAGAGTCTATATTTCATGAGTTCAAAC
ATGTTGTTTCCCATTCGGATTACATGGAGTTATATAAAATTCCTTCTTTTAGAAATAAGATGGAAGCTGAGGCAGATCAT
CATATGTTTAAATGCCTTATTGAAAAACATGAAGGTCAGTTTAATTATTCTAATGTGGTTACCCATTACAATTTAAAGAT
GGGACAGGAAACTTATTTAAAATAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12088.81 Da        Isoelectric Point: 6.4689

>AT206011 WP_004155188.1 NZ_CP076594:c3119967-3119644 [Erwinia amylovora]
MSITLPHEWGLQSDITPRFGARLVQEGNRLYYLADRAGLTVSFSPIHLQKLDQAFPLFVEQLENMLRAGELNPHQQHQVT
IQLTSLTCIADTRGSCGYVYISIYPTP

Download         Length: 324 bp

>AT206011 NZ_CP102065:1709624-1709956 [Enterococcus faecalis]
ATGAACCTTTTGGAACGTATAAAAAAACTAGCAAAAGATAGAGATGTGTCTATTTATCAGCTTGAAGAAGAAATAAATAT
TGGACGAAATACTATTTATCAATGGAATAAGCGAACACCTTCTTCGGATAAACTTGAAGCTGTAGCCAATTATTTTAATG
TTTCTGTTGATTATTTATTAGGTCGTACTGAAAATCCAAACCAAGCTGGTGCTAAACCATCTGATGATTTAGATGAAGTA
TTAGACAATGTGATGAGTTTTGACGGTGAGCCTTTGGATGATCATGATCGAGAAGTTATTCGTGCTTACTTAAAAGGAAG
ATTCGGAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A831EPU6

Antitoxin

Source ID Structure
AlphaFold DB A0A831ENV6

References