Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
Location | 3119287..3119967 | Replicon | chromosome |
Accession | NZ_CP076594 | ||
Organism | Erwinia amylovora isolate CP20086202 |
Toxin (Protein)
Gene name | yeeV | Uniprot ID | D4HV69 |
Locus tag | KQH36_RS14190 | Protein ID | WP_004155189.1 |
Coordinates | 3119287..3119607 (-) | Length | 107 a.a. |
Antitoxin (Protein)
Gene name | yeeU | Uniprot ID | D4HV68 |
Locus tag | KQH36_RS14195 | Protein ID | WP_004155188.1 |
Coordinates | 3119644..3119967 (-) | Length | 108 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KQH36_RS14170 (KQH36_14165) | 3117098..3117298 | - | 201 | Protein_2739 | transposase | - |
KQH36_RS14175 (KQH36_14170) | 3117717..3117992 | - | 276 | WP_004155192.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
KQH36_RS14180 (KQH36_14175) | 3117996..3118244 | - | 249 | WP_004155191.1 | ribbon-helix-helix domain-containing protein | - |
KQH36_RS14185 (KQH36_14180) | 3118341..3119174 | - | 834 | WP_004155190.1 | DUF4942 domain-containing protein | - |
KQH36_RS14190 (KQH36_14185) | 3119287..3119607 | - | 321 | WP_004155189.1 | TA system toxin CbtA family protein | Toxin |
KQH36_RS14195 (KQH36_14190) | 3119644..3119967 | - | 324 | WP_004155188.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
KQH36_RS14200 (KQH36_14195) | 3119980..3120450 | - | 471 | WP_004155187.1 | DNA repair protein RadC | - |
KQH36_RS14205 (KQH36_14200) | 3120521..3121095 | - | 575 | Protein_2746 | DUF932 domain-containing protein | - |
KQH36_RS14210 (KQH36_14205) | 3121320..3121562 | - | 243 | WP_004155184.1 | hypothetical protein | - |
KQH36_RS14215 (KQH36_14210) | 3122772..3122969 | + | 198 | WP_004155182.1 | AlpA family phage regulatory protein | - |
KQH36_RS14220 | 3123077..3123427 | + | 351 | WP_004155181.1 | hypothetical protein | - |
KQH36_RS14225 (KQH36_14220) | 3123871..3124956 | + | 1086 | WP_004155179.1 | DNA sulfur modification protein DndB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Genomic island | - | - | 3117326..3140888 | 23562 | ||
flank | IS/Tn | - | - | 3117074..3117298 | 224 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 107 a.a. Molecular weight: 12023.69 Da Isoelectric Point: 5.4732
>T206011 WP_004155189.1 NZ_CP076594:c3119607-3119287 [Erwinia amylovora]
MHISTVPATVPVSSRLSPVQVWQQLLTYLLEHHYGLTLNDTPFHDDAAIEEHIDAGITLADAVNFLVERYELVRIDRKGF
TWQEQTPFLAATDILRARRATGLINI
MHISTVPATVPVSSRLSPVQVWQQLLTYLLEHHYGLTLNDTPFHDDAAIEEHIDAGITLADAVNFLVERYELVRIDRKGF
TWQEQTPFLAATDILRARRATGLINI
Download Length: 321 bp
>T206011 NZ_CP102065:1709974-1710318 [Enterococcus faecalis]
ATGAAAAGTATCAAAGAGTTGGTGGAAGAATATGAAGTAGAGTTAGTTTTTGCTCCAATAAATAAGCGCGCATGTTACGA
GCCAAGTGAAAGGATAATTTTCGTTAATCAAAATTTATCTATCGAAGAACAAGAAGAGTCTATATTTCATGAGTTCAAAC
ATGTTGTTTCCCATTCGGATTACATGGAGTTATATAAAATTCCTTCTTTTAGAAATAAGATGGAAGCTGAGGCAGATCAT
CATATGTTTAAATGCCTTATTGAAAAACATGAAGGTCAGTTTAATTATTCTAATGTGGTTACCCATTACAATTTAAAGAT
GGGACAGGAAACTTATTTAAAATAA
ATGAAAAGTATCAAAGAGTTGGTGGAAGAATATGAAGTAGAGTTAGTTTTTGCTCCAATAAATAAGCGCGCATGTTACGA
GCCAAGTGAAAGGATAATTTTCGTTAATCAAAATTTATCTATCGAAGAACAAGAAGAGTCTATATTTCATGAGTTCAAAC
ATGTTGTTTCCCATTCGGATTACATGGAGTTATATAAAATTCCTTCTTTTAGAAATAAGATGGAAGCTGAGGCAGATCAT
CATATGTTTAAATGCCTTATTGAAAAACATGAAGGTCAGTTTAATTATTCTAATGTGGTTACCCATTACAATTTAAAGAT
GGGACAGGAAACTTATTTAAAATAA
Antitoxin
Download Length: 108 a.a. Molecular weight: 12088.81 Da Isoelectric Point: 6.4689
>AT206011 WP_004155188.1 NZ_CP076594:c3119967-3119644 [Erwinia amylovora]
MSITLPHEWGLQSDITPRFGARLVQEGNRLYYLADRAGLTVSFSPIHLQKLDQAFPLFVEQLENMLRAGELNPHQQHQVT
IQLTSLTCIADTRGSCGYVYISIYPTP
MSITLPHEWGLQSDITPRFGARLVQEGNRLYYLADRAGLTVSFSPIHLQKLDQAFPLFVEQLENMLRAGELNPHQQHQVT
IQLTSLTCIADTRGSCGYVYISIYPTP
Download Length: 324 bp
>AT206011 NZ_CP102065:1709624-1709956 [Enterococcus faecalis]
ATGAACCTTTTGGAACGTATAAAAAAACTAGCAAAAGATAGAGATGTGTCTATTTATCAGCTTGAAGAAGAAATAAATAT
TGGACGAAATACTATTTATCAATGGAATAAGCGAACACCTTCTTCGGATAAACTTGAAGCTGTAGCCAATTATTTTAATG
TTTCTGTTGATTATTTATTAGGTCGTACTGAAAATCCAAACCAAGCTGGTGCTAAACCATCTGATGATTTAGATGAAGTA
TTAGACAATGTGATGAGTTTTGACGGTGAGCCTTTGGATGATCATGATCGAGAAGTTATTCGTGCTTACTTAAAAGGAAG
ATTCGGAAAATAA
ATGAACCTTTTGGAACGTATAAAAAAACTAGCAAAAGATAGAGATGTGTCTATTTATCAGCTTGAAGAAGAAATAAATAT
TGGACGAAATACTATTTATCAATGGAATAAGCGAACACCTTCTTCGGATAAACTTGAAGCTGTAGCCAATTATTTTAATG
TTTCTGTTGATTATTTATTAGGTCGTACTGAAAATCCAAACCAAGCTGGTGCTAAACCATCTGATGATTTAGATGAAGTA
TTAGACAATGTGATGAGTTTTGACGGTGAGCCTTTGGATGATCATGATCGAGAAGTTATTCGTGCTTACTTAAAAGGAAG
ATTCGGAAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A831EPU6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A831ENV6 |