294492

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/-
Location 3404618..3405145 Replicon chromosome
Accession NZ_NQJO01000001
Organism Erwinia amylovora strain CTBT3-1 tig00000000

Toxin (Protein)


Gene name relE Uniprot ID D4HV72
Locus tag CS942_RS16085 Protein ID WP_004155192.1
Coordinates 3404618..3404893 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D4HV71
Locus tag CS942_RS16090 Protein ID WP_004155191.1
Coordinates 3404897..3405145 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CS942_RS16075 3400337..3403702 + 3366 WP_004155194.1 ATP-binding protein -
CS942_RS16080 3403999..3404199 - 201 Protein_3033 transposase -
CS942_RS16085 3404618..3404893 - 276 WP_004155192.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CS942_RS16090 3404897..3405145 - 249 WP_004155191.1 ribbon-helix-helix domain-containing protein Antitoxin
CS942_RS16095 3405242..3406075 - 834 WP_004155190.1 DUF4942 domain-containing protein -
CS942_RS16100 3406188..3406508 - 321 WP_004155189.1 TA system toxin CbtA family protein -
CS942_RS16105 3406545..3406868 - 324 WP_004155188.1 type IV toxin-antitoxin system YeeU family antitoxin -
CS942_RS16110 3406881..3407351 - 471 WP_004155187.1 DNA repair protein RadC -
CS942_RS16115 3407422..3407996 - 575 Protein_3040 DUF932 domain-containing protein -
CS942_RS16120 3408221..3408463 - 243 WP_004155184.1 hypothetical protein -
CS942_RS16130 3409673..3409870 + 198 WP_004155182.1 AlpA family phage regulatory protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3404618..3427747 23129
flank IS/Tn - - 3403975..3404199 224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 11108.44 Da        Isoelectric Point: 5.5782

>T294492 WP_004155192.1 NZ_NQJO01000001:c3404893-3404618 [Erwinia amylovora]
MEIQWTQKAQDDLERIYRFACQYSRQHADNVLERLLIGTSGLADHPRIGVSQIRYEPREVRKILFDDYDVHYEIQRDTIY
IVDLWHTREDR

Download         Length: 276 bp

>T294492 NZ_NQJO01000001:c3404893-3404618 [Erwinia amylovora]
ATGGAAATACAGTGGACCCAAAAGGCCCAGGATGACCTGGAGCGTATTTATAGGTTTGCCTGTCAGTACAGTCGGCAACA
TGCTGACAACGTATTAGAGCGTTTGCTCATAGGAACCTCAGGGCTCGCCGACCATCCAAGAATCGGTGTTTCTCAGATAA
GATATGAACCACGAGAAGTGAGAAAAATCTTGTTTGATGATTATGACGTTCACTATGAAATTCAGCGCGACACTATCTAT
ATTGTTGACCTTTGGCATACCCGAGAGGATCGCTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9121.53 Da        Isoelectric Point: 8.7560

>AT294492 WP_004155191.1 NZ_NQJO01000001:c3405145-3404897 [Erwinia amylovora]
MRQLAKQTISAQIPAELAAAVENLAIELDRSKSWVIKEALTAMIEERERRHQQILKGLADVDAGRVVSHADVVDFANKLK
KS

Download         Length: 249 bp

>AT294492 NZ_NQJO01000001:c3405145-3404897 [Erwinia amylovora]
ATGAGACAACTCGCGAAACAGACGATCAGCGCTCAGATCCCTGCAGAGCTTGCCGCGGCGGTTGAAAACCTGGCTATTGA
ACTGGACAGATCTAAAAGCTGGGTGATTAAAGAAGCGCTGACCGCCATGATTGAAGAGAGAGAGCGGCGGCATCAGCAGA
TTTTGAAAGGGCTTGCTGATGTCGATGCGGGAAGAGTGGTTAGCCATGCGGATGTAGTTGACTTCGCTAACAAACTGAAA
AAATCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A831EQZ9

Antitoxin

Source ID Structure
AlphaFold DB A0A831A0W7

References