205962

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 592529..593209 Replicon chromosome
Accession NZ_CP076589
Organism Erwinia amylovora isolate CP201324

Toxin (Protein)


Gene name yeeV Uniprot ID D4HV69
Locus tag KQH38_RS02635 Protein ID WP_004155189.1
Coordinates 592889..593209 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID D4HV68
Locus tag KQH38_RS02630 Protein ID WP_004155188.1
Coordinates 592529..592852 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQH38_RS02600 (KQH38_02605) 587540..588625 - 1086 WP_004155179.1 DNA sulfur modification protein DndB -
KQH38_RS02605 589069..589419 - 351 WP_004155181.1 hypothetical protein -
KQH38_RS02610 (KQH38_02615) 589527..589724 - 198 WP_004155182.1 AlpA family phage regulatory protein -
KQH38_RS02615 (KQH38_02620) 590934..591176 + 243 WP_004155184.1 hypothetical protein -
KQH38_RS02620 (KQH38_02625) 591401..591975 + 575 Protein_509 DUF932 domain-containing protein -
KQH38_RS02625 (KQH38_02630) 592046..592516 + 471 WP_004155187.1 DNA repair protein RadC -
KQH38_RS02630 (KQH38_02635) 592529..592852 + 324 WP_004155188.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KQH38_RS02635 (KQH38_02640) 592889..593209 + 321 WP_004155189.1 TA system toxin CbtA family protein Toxin
KQH38_RS02640 (KQH38_02645) 593322..594155 + 834 WP_004155190.1 DUF4942 domain-containing protein -
KQH38_RS02645 (KQH38_02650) 594252..594500 + 249 WP_004155191.1 ribbon-helix-helix domain-containing protein -
KQH38_RS02650 (KQH38_02655) 594504..594779 + 276 WP_004155192.1 type II toxin-antitoxin system RelE/ParE family toxin -
KQH38_RS02655 (KQH38_02660) 595198..595398 + 201 Protein_516 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 571608..595546 23938
flank IS/Tn - - 595198..595422 224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(5-105)

Antitoxin

Antitoxin CbeA

(7-106)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12023.69 Da        Isoelectric Point: 5.4732

>T205962 WP_004155189.1 NZ_CP076589:592889-593209 [Erwinia amylovora]
MHISTVPATVPVSSRLSPVQVWQQLLTYLLEHHYGLTLNDTPFHDDAAIEEHIDAGITLADAVNFLVERYELVRIDRKGF
TWQEQTPFLAATDILRARRATGLINI

Download         Length: 321 bp

>T205962 NZ_CP101940:3435930-3436298 [Salmonella enterica subsp. enterica]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAAGCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGTGCCTGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12088.81 Da        Isoelectric Point: 6.4689

>AT205962 WP_004155188.1 NZ_CP076589:592529-592852 [Erwinia amylovora]
MSITLPHEWGLQSDITPRFGARLVQEGNRLYYLADRAGLTVSFSPIHLQKLDQAFPLFVEQLENMLRAGELNPHQQHQVT
IQLTSLTCIADTRGSCGYVYISIYPTP

Download         Length: 324 bp

>AT205962 NZ_CP101940:3435712-3435933 [Salmonella enterica subsp. enterica]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGTGCGGTGACGGGGGGGCCTGTTAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A831EPU6

Antitoxin

Source ID Structure
AlphaFold DB A0A831ENV6

References