24691

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 3302350..3302877 Replicon chromosome
Accession NC_013971
Organism Erwinia amylovora ATCC 49946

Toxin (Protein)


Gene name relE Uniprot ID D4HV72
Locus tag EAM_RS14780 Protein ID WP_004155192.1
Coordinates 3302350..3302625 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D4HV71
Locus tag EAM_RS14785 Protein ID WP_004155191.1
Coordinates 3302629..3302877 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EAM_RS14770 (EAM_3014) 3298069..3301434 + 3366 WP_004155194.1 ATP-binding protein -
EAM_RS14775 (EAM_3015) 3301731..3301931 - 201 Protein_2882 transposase -
EAM_RS14780 (EAM_3017) 3302350..3302625 - 276 WP_004155192.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EAM_RS14785 (EAM_3018) 3302629..3302877 - 249 WP_004155191.1 ribbon-helix-helix domain-containing protein Antitoxin
EAM_RS14790 (EAM_3019) 3302974..3303807 - 834 WP_004155190.1 DUF4942 domain-containing protein -
EAM_RS14795 (EAM_3020) 3303920..3304240 - 321 WP_004155189.1 TA system toxin CbtA family protein -
EAM_RS14800 (EAM_3021) 3304277..3304600 - 324 WP_004155188.1 type IV toxin-antitoxin system YeeU family antitoxin -
EAM_RS14805 (EAM_3022) 3304613..3305083 - 471 WP_004155187.1 DNA repair protein RadC -
EAM_RS18595 (EAM_3023) 3305154..3305728 - 575 Protein_2889 DUF932 domain-containing protein -
EAM_RS18600 (EAM_3024) 3305953..3306195 - 243 WP_004155184.1 hypothetical protein -
EAM_RS14820 (EAM_3026) 3307405..3307602 + 198 WP_004155182.1 AlpA family phage regulatory protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 3301707..3301931 224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 11108.44 Da        Isoelectric Point: 5.5782

>T24691 WP_004155192.1 NC_013971:c3302625-3302350 [Erwinia amylovora ATCC 49946]
MEIQWTQKAQDDLERIYRFACQYSRQHADNVLERLLIGTSGLADHPRIGVSQIRYEPREVRKILFDDYDVHYEIQRDTIY
IVDLWHTREDR

Download         Length: 276 bp

>T24691 NC_013971:c3302625-3302350 [Erwinia amylovora ATCC 49946]
ATGGAAATACAGTGGACCCAAAAGGCCCAGGATGACCTGGAGCGTATTTATAGGTTTGCCTGTCAGTACAGTCGGCAACA
TGCTGACAACGTATTAGAGCGTTTGCTCATAGGAACCTCAGGGCTCGCCGACCATCCAAGAATCGGTGTTTCTCAGATAA
GATATGAACCACGAGAAGTGAGAAAAATCTTGTTTGATGATTATGACGTTCACTATGAAATTCAGCGCGACACTATCTAT
ATTGTTGACCTTTGGCATACCCGAGAGGATCGCTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9121.53 Da        Isoelectric Point: 8.7560

>AT24691 WP_004155191.1 NC_013971:c3302877-3302629 [Erwinia amylovora ATCC 49946]
MRQLAKQTISAQIPAELAAAVENLAIELDRSKSWVIKEALTAMIEERERRHQQILKGLADVDAGRVVSHADVVDFANKLK
KS

Download         Length: 249 bp

>AT24691 NC_013971:c3302877-3302629 [Erwinia amylovora ATCC 49946]
ATGAGACAACTCGCGAAACAGACGATCAGCGCTCAGATCCCTGCAGAGCTTGCCGCGGCGGTTGAAAACCTGGCTATTGA
ACTGGACAGATCTAAAAGCTGGGTGATTAAAGAAGCGCTGACCGCCATGATTGAAGAGAGAGAGCGGCGGCATCAGCAGA
TTTTGAAAGGGCTTGCTGATGTCGATGCGGGAAGAGTGGTTAGCCATGCGGATGTAGTTGACTTCGCTAACAAACTGAAA
AAATCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A831EQZ9

Antitoxin

Source ID Structure
AlphaFold DB A0A831A0W7

References