206027

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 2314805..2315332 Replicon chromosome
Accession NZ_CP076596
Organism Erwinia amylovora isolate CP20161301

Toxin (Protein)


Gene name relE Uniprot ID D4HV72
Locus tag KQH32_RS10355 Protein ID WP_004155192.1
Coordinates 2315057..2315332 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D4HV71
Locus tag KQH32_RS10350 Protein ID WP_004155191.1
Coordinates 2314805..2315053 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQH32_RS10315 (KQH32_10340) 2310080..2310277 - 198 WP_004155182.1 AlpA family phage regulatory protein -
KQH32_RS10320 (KQH32_10345) 2311487..2311729 + 243 WP_004155184.1 hypothetical protein -
KQH32_RS10325 (KQH32_10350) 2311954..2312528 + 575 Protein_1991 DUF932 domain-containing protein -
KQH32_RS10330 (KQH32_10355) 2312599..2313069 + 471 WP_004155187.1 DNA repair protein RadC -
KQH32_RS10335 (KQH32_10360) 2313082..2313405 + 324 WP_004155188.1 type IV toxin-antitoxin system YeeU family antitoxin -
KQH32_RS10340 (KQH32_10365) 2313442..2313762 + 321 WP_004155189.1 TA system toxin CbtA family protein -
KQH32_RS10345 (KQH32_10370) 2313875..2314708 + 834 WP_004155190.1 DUF4942 domain-containing protein -
KQH32_RS10350 (KQH32_10375) 2314805..2315053 + 249 WP_004155191.1 ribbon-helix-helix domain-containing protein Antitoxin
KQH32_RS10355 (KQH32_10380) 2315057..2315332 + 276 WP_004155192.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KQH32_RS10360 (KQH32_10385) 2315751..2315951 + 201 Protein_1998 transposase -
KQH32_RS10365 (KQH32_10395) 2316248..2319613 - 3366 WP_004155194.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2292161..2316099 23938
flank IS/Tn - - 2315751..2315975 224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 11108.44 Da        Isoelectric Point: 5.5782

>T206027 WP_004155192.1 NZ_CP076596:2315057-2315332 [Erwinia amylovora]
MEIQWTQKAQDDLERIYRFACQYSRQHADNVLERLLIGTSGLADHPRIGVSQIRYEPREVRKILFDDYDVHYEIQRDTIY
IVDLWHTREDR

Download         Length: 276 bp

>T206027 NZ_CP102072:c9400-8537 [Enterococcus faecalis]
ATGGCAAATATAGTCAATTTTACTGACAAACAATTTGAGAATCGCTTAAATGATAATTTAGAAGAATTGATTCAAGGAAA
AAAAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGGAAAACCAGTTTGCGATCAGCAATTT
TTGAAGAAACACAAGGGAATGTTATTGTCATTGATAATGATACCTTTAAACAACAGCACCCTAATTTTGATGAACTAGTG
AAACTTTATGAAAAAGACGTAGTAAAACACGTTACCCCTTATTCTAATCGCATGACAGAAGCGATCATAAGCCGTTTGAG
CGATCAAGGGTATAATTTGGTGATCGAAGGTACAGGACGAACAACAGACGTTCCTATTCAAACCGCAACAATGCTTCAAG
CCAAAGGTTATGAAACAAAAATGTATGTCATGGCAGTACCTAAAATCAACTCATATTTAGGAACAATTGAACGATATGAA
ACCATGTATGCAGATGATCCAATGACAGCCAGGGCAACACCAAAACAAGCGCATGATATTGTTGTCAAAAACTTACCGAC
CAATTTAGAAACCCTTCATAAAACGGGCTTATTTAGCGATATAAGGCTATATAACAGAGAAGGAGTAAAACTCTATTCAA
GTTTGGAAACACCTTCTATTAGTCCAAAAGAAACCTTAGAAAAAGAATTGAATCGTAAAGTATCAGGGAAAGAAATTCAA
CCGACTTTAGAACGAATAGAGCAAAAAATGGTTCTAAATAAACACCAAGAGACACCTGAATTTAAAGCAATTCAACAAAA
ATTGGAAAGCTTGCAGCCACCTACACCACCAATACCCAAAACACCTAAACTTCCAGGTATTTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9121.53 Da        Isoelectric Point: 8.7560

>AT206027 WP_004155191.1 NZ_CP076596:2314805-2315053 [Erwinia amylovora]
MRQLAKQTISAQIPAELAAAVENLAIELDRSKSWVIKEALTAMIEERERRHQQILKGLADVDAGRVVSHADVVDFANKLK
KS

Download         Length: 249 bp

>AT206027 NZ_CP102072:c9674-9402 [Enterococcus faecalis]
ATGGCAGTTACGTATGAAAAAACATTTGAAATAGAGATCATTAACGAATTATCGGCAAGCGTTTATAATCGAGTATTAAA
CTATGTTTTGAACCATGAATTAAATAAAAATGACTCTCAATTATTGGAAGTCAATTTATTAAACCAATTAAAGCTTGCAA
AACGTGTAAATCTTTTTGATTATTCTTTAGAAGAATTACAAGCCGTTCATGAGTATTGGCGGTCAATGAATCGTTACTCA
AAACAAGTTTTGAATAAAGAGAAAGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A831EQZ9

Antitoxin

Source ID Structure
AlphaFold DB A0A831A0W7

References