206026

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2313082..2313762 Replicon chromosome
Accession NZ_CP076596
Organism Erwinia amylovora isolate CP20161301

Toxin (Protein)


Gene name yeeV Uniprot ID D4HV69
Locus tag KQH32_RS10340 Protein ID WP_004155189.1
Coordinates 2313442..2313762 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID D4HV68
Locus tag KQH32_RS10335 Protein ID WP_004155188.1
Coordinates 2313082..2313405 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQH32_RS10305 (KQH32_10330) 2308093..2309178 - 1086 WP_004155179.1 DNA sulfur modification protein DndB -
KQH32_RS10310 2309622..2309972 - 351 WP_004155181.1 hypothetical protein -
KQH32_RS10315 (KQH32_10340) 2310080..2310277 - 198 WP_004155182.1 AlpA family phage regulatory protein -
KQH32_RS10320 (KQH32_10345) 2311487..2311729 + 243 WP_004155184.1 hypothetical protein -
KQH32_RS10325 (KQH32_10350) 2311954..2312528 + 575 Protein_1991 DUF932 domain-containing protein -
KQH32_RS10330 (KQH32_10355) 2312599..2313069 + 471 WP_004155187.1 DNA repair protein RadC -
KQH32_RS10335 (KQH32_10360) 2313082..2313405 + 324 WP_004155188.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KQH32_RS10340 (KQH32_10365) 2313442..2313762 + 321 WP_004155189.1 TA system toxin CbtA family protein Toxin
KQH32_RS10345 (KQH32_10370) 2313875..2314708 + 834 WP_004155190.1 DUF4942 domain-containing protein -
KQH32_RS10350 (KQH32_10375) 2314805..2315053 + 249 WP_004155191.1 ribbon-helix-helix domain-containing protein -
KQH32_RS10355 (KQH32_10380) 2315057..2315332 + 276 WP_004155192.1 type II toxin-antitoxin system RelE/ParE family toxin -
KQH32_RS10360 (KQH32_10385) 2315751..2315951 + 201 Protein_1998 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2292161..2316099 23938
flank IS/Tn - - 2315751..2315975 224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(5-105)

Antitoxin

Antitoxin CbeA

(7-106)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12023.69 Da        Isoelectric Point: 5.4732

>T206026 WP_004155189.1 NZ_CP076596:2313442-2313762 [Erwinia amylovora]
MHISTVPATVPVSSRLSPVQVWQQLLTYLLEHHYGLTLNDTPFHDDAAIEEHIDAGITLADAVNFLVERYELVRIDRKGF
TWQEQTPFLAATDILRARRATGLINI

Download         Length: 321 bp

>T206026 NZ_CP102070:2793208-2793351 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTTAAAGAAGACAATAAAAAATAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12088.81 Da        Isoelectric Point: 6.4689

>AT206026 WP_004155188.1 NZ_CP076596:2313082-2313405 [Erwinia amylovora]
MSITLPHEWGLQSDITPRFGARLVQEGNRLYYLADRAGLTVSFSPIHLQKLDQAFPLFVEQLENMLRAGELNPHQQHQVT
IQLTSLTCIADTRGSCGYVYISIYPTP

Download         Length: 324 bp

>AT206026 NZ_CP102070:c2793545-2793283 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGATGGTCGTTGTGCTATA
ATAGTAATGAAAAGAGAGGTATGCGCCAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTCTTCTTTAACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A831EPU6

Antitoxin

Source ID Structure
AlphaFold DB A0A831ENV6

References