162504

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 471518..472045 Replicon chromosome
Accession NZ_CP056034
Organism Erwinia amylovora strain TS3128

Toxin (Protein)


Gene name relE Uniprot ID D4HV72
Locus tag HU055_RS02185 Protein ID WP_004155192.1
Coordinates 471770..472045 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D4HV71
Locus tag HU055_RS02180 Protein ID WP_004155191.1
Coordinates 471518..471766 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HU055_RS02145 466793..466990 - 198 WP_004155182.1 AlpA family phage regulatory protein -
HU055_RS02150 468200..468442 + 243 WP_004155184.1 hypothetical protein -
HU055_RS02155 468667..469241 + 575 Protein_421 DUF932 domain-containing protein -
HU055_RS02160 469312..469782 + 471 WP_004155187.1 DNA repair protein RadC -
HU055_RS02165 469795..470118 + 324 WP_004155188.1 type IV toxin-antitoxin system YeeU family antitoxin -
HU055_RS02170 470155..470475 + 321 WP_004155189.1 TA system toxin CbtA family protein -
HU055_RS02175 470588..471421 + 834 WP_004155190.1 DUF4942 domain-containing protein -
HU055_RS02180 471518..471766 + 249 WP_004155191.1 ribbon-helix-helix domain-containing protein Antitoxin
HU055_RS02185 471770..472045 + 276 WP_004155192.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HU055_RS02190 472464..472664 + 201 Protein_428 transposase -
HU055_RS02195 472660..472812 + 153 WP_004163933.1 hypothetical protein -
HU055_RS02200 472961..476326 - 3366 WP_004155194.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 448874..472812 23938
flank IS/Tn - - 472464..472688 224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 11108.44 Da        Isoelectric Point: 5.5782

>T162504 WP_004155192.1 NZ_CP056034:471770-472045 [Erwinia amylovora]
MEIQWTQKAQDDLERIYRFACQYSRQHADNVLERLLIGTSGLADHPRIGVSQIRYEPREVRKILFDDYDVHYEIQRDTIY
IVDLWHTREDR

Download         Length: 276 bp

>T162504 NZ_CP071821:c89821-89405 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGACCGGATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGATGCGTTCTGCGCGCGCCTCGATGCTGTCCTGCCCTGGGACCGCGCC
GCAGTGGACGCCACGACGGACATCCGAGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATAGC
CGGCCACGCCATCGCGGCCGGCGCCGTCCTGGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9121.53 Da        Isoelectric Point: 8.7560

>AT162504 WP_004155191.1 NZ_CP056034:471518-471766 [Erwinia amylovora]
MRQLAKQTISAQIPAELAAAVENLAIELDRSKSWVIKEALTAMIEERERRHQQILKGLADVDAGRVVSHADVVDFANKLK
KS

Download         Length: 249 bp

>AT162504 NZ_CP071821:c90048-89818 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGTGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGAGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCATTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGTGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A831EQZ9

Antitoxin

Source ID Structure
AlphaFold DB A0A831A0W7

References