152399

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3301637..3302317 Replicon chromosome
Accession NZ_CP050240
Organism Erwinia amylovora strain FB-20

Toxin (Protein)


Gene name yeeV Uniprot ID D4HV69
Locus tag EGZ89_RS14930 Protein ID WP_004155189.1
Coordinates 3301637..3301957 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID D4HV68
Locus tag EGZ89_RS14935 Protein ID WP_004155188.1
Coordinates 3301994..3302317 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGZ89_RS14905 3299300..3299452 - 153 WP_004163933.1 hypothetical protein -
EGZ89_RS14910 3299448..3299648 - 201 Protein_2872 transposase -
EGZ89_RS14915 3300067..3300342 - 276 WP_004155192.1 type II toxin-antitoxin system RelE/ParE family toxin -
EGZ89_RS14920 3300346..3300594 - 249 WP_004155191.1 ribbon-helix-helix domain-containing protein -
EGZ89_RS14925 3300691..3301524 - 834 WP_004155190.1 DUF4942 domain-containing protein -
EGZ89_RS14930 3301637..3301957 - 321 WP_004155189.1 TA system toxin CbtA family protein Toxin
EGZ89_RS14935 3301994..3302317 - 324 WP_004155188.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EGZ89_RS14940 3302330..3302800 - 471 WP_004155187.1 DNA repair protein RadC -
EGZ89_RS14945 3302871..3303445 - 575 Protein_2879 DUF932 domain-containing protein -
EGZ89_RS14950 3303670..3303912 - 243 WP_004155184.1 hypothetical protein -
EGZ89_RS14955 3305122..3305319 + 198 WP_004155182.1 AlpA family phage regulatory protein -
EGZ89_RS14960 3305427..3306021 + 595 Protein_2882 hypothetical protein -
EGZ89_RS14965 3306221..3307306 + 1086 WP_004155179.1 DNA sulfur modification protein DndB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3299676..3323238 23562
flank IS/Tn - - 3299424..3299648 224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(5-105)

Antitoxin

Antitoxin CbeA

(7-106)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12023.69 Da        Isoelectric Point: 5.4732

>T152399 WP_004155189.1 NZ_CP050240:c3301957-3301637 [Erwinia amylovora]
MHISTVPATVPVSSRLSPVQVWQQLLTYLLEHHYGLTLNDTPFHDDAAIEEHIDAGITLADAVNFLVERYELVRIDRKGF
TWQEQTPFLAATDILRARRATGLINI

Download         Length: 321 bp

>T152399 NZ_CP066144:c830719-830342 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCAACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12088.81 Da        Isoelectric Point: 6.4689

>AT152399 WP_004155188.1 NZ_CP050240:c3302317-3301994 [Erwinia amylovora]
MSITLPHEWGLQSDITPRFGARLVQEGNRLYYLADRAGLTVSFSPIHLQKLDQAFPLFVEQLENMLRAGELNPHQQHQVT
IQLTSLTCIADTRGSCGYVYISIYPTP

Download         Length: 324 bp

>AT152399 NZ_CP066144:c831176-830796 [Escherichia coli]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCTCCCCTGGTGGGGGCTGCCCTGCGCCGTGAC
ACCTTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGGGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGGTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A831EPU6

Antitoxin

Source ID Structure
AlphaFold DB A0A831ENV6

References