Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 2327441..2327968 Replicon chromosome
Accession NZ_CP076592
Organism Erwinia amylovora isolate CP20140001

Toxin (Protein)


Gene name relE Uniprot ID D4HV72
Locus tag KQH33_RS10405 Protein ID WP_004155192.1
Coordinates 2327693..2327968 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D4HV71
Locus tag KQH33_RS10400 Protein ID WP_004155191.1
Coordinates 2327441..2327689 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQH33_RS10365 (KQH33_10390) 2322716..2322913 - 198 WP_004155182.1 AlpA family phage regulatory protein -
KQH33_RS10370 (KQH33_10395) 2324123..2324365 + 243 WP_004155184.1 hypothetical protein -
KQH33_RS10375 (KQH33_10400) 2324590..2325164 + 575 Protein_2002 DUF932 domain-containing protein -
KQH33_RS10380 (KQH33_10405) 2325235..2325705 + 471 WP_004155187.1 DNA repair protein RadC -
KQH33_RS10385 (KQH33_10410) 2325718..2326041 + 324 WP_004155188.1 type IV toxin-antitoxin system YeeU family antitoxin -
KQH33_RS10390 (KQH33_10415) 2326078..2326398 + 321 WP_004155189.1 TA system toxin CbtA family protein -
KQH33_RS10395 (KQH33_10420) 2326511..2327344 + 834 WP_004155190.1 DUF4942 domain-containing protein -
KQH33_RS10400 (KQH33_10425) 2327441..2327689 + 249 WP_004155191.1 ribbon-helix-helix domain-containing protein Antitoxin
KQH33_RS10405 (KQH33_10430) 2327693..2327968 + 276 WP_004155192.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KQH33_RS10410 (KQH33_10435) 2328387..2328587 + 201 Protein_2009 transposase -
KQH33_RS10415 (KQH33_10445) 2328884..2332249 - 3366 WP_004155194.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2304797..2328735 23938
flank IS/Tn - - 2328387..2328611 224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 11108.44 Da        Isoelectric Point: 5.5782

>T205997 WP_004155192.1 NZ_CP076592:2327693-2327968 [Erwinia amylovora]
MEIQWTQKAQDDLERIYRFACQYSRQHADNVLERLLIGTSGLADHPRIGVSQIRYEPREVRKILFDDYDVHYEIQRDTIY
IVDLWHTREDR

Download         Length: 276 bp

>T205997 NZ_CP102061:c2609639-2609532 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9121.53 Da        Isoelectric Point: 8.7560

>AT205997 WP_004155191.1 NZ_CP076592:2327441-2327689 [Erwinia amylovora]
MRQLAKQTISAQIPAELAAAVENLAIELDRSKSWVIKEALTAMIEERERRHQQILKGLADVDAGRVVSHADVVDFANKLK
KS

Download         Length: 249 bp

>AT205997 NZ_CP102061:2609688-2609753 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A831EQZ9

Antitoxin

Source ID Structure
AlphaFold DB A0A831A0W7

References