Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/RHH(antitoxin) |
Location | 2327441..2327968 | Replicon | chromosome |
Accession | NZ_CP076592 | ||
Organism | Erwinia amylovora isolate CP20140001 |
Toxin (Protein)
Gene name | relE | Uniprot ID | D4HV72 |
Locus tag | KQH33_RS10405 | Protein ID | WP_004155192.1 |
Coordinates | 2327693..2327968 (+) | Length | 92 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | D4HV71 |
Locus tag | KQH33_RS10400 | Protein ID | WP_004155191.1 |
Coordinates | 2327441..2327689 (+) | Length | 83 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KQH33_RS10365 (KQH33_10390) | 2322716..2322913 | - | 198 | WP_004155182.1 | AlpA family phage regulatory protein | - |
KQH33_RS10370 (KQH33_10395) | 2324123..2324365 | + | 243 | WP_004155184.1 | hypothetical protein | - |
KQH33_RS10375 (KQH33_10400) | 2324590..2325164 | + | 575 | Protein_2002 | DUF932 domain-containing protein | - |
KQH33_RS10380 (KQH33_10405) | 2325235..2325705 | + | 471 | WP_004155187.1 | DNA repair protein RadC | - |
KQH33_RS10385 (KQH33_10410) | 2325718..2326041 | + | 324 | WP_004155188.1 | type IV toxin-antitoxin system YeeU family antitoxin | - |
KQH33_RS10390 (KQH33_10415) | 2326078..2326398 | + | 321 | WP_004155189.1 | TA system toxin CbtA family protein | - |
KQH33_RS10395 (KQH33_10420) | 2326511..2327344 | + | 834 | WP_004155190.1 | DUF4942 domain-containing protein | - |
KQH33_RS10400 (KQH33_10425) | 2327441..2327689 | + | 249 | WP_004155191.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
KQH33_RS10405 (KQH33_10430) | 2327693..2327968 | + | 276 | WP_004155192.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
KQH33_RS10410 (KQH33_10435) | 2328387..2328587 | + | 201 | Protein_2009 | transposase | - |
KQH33_RS10415 (KQH33_10445) | 2328884..2332249 | - | 3366 | WP_004155194.1 | ATP-binding protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Genomic island | - | - | 2304797..2328735 | 23938 | ||
flank | IS/Tn | - | - | 2328387..2328611 | 224 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 11108.44 Da Isoelectric Point: 5.5782
>T205997 WP_004155192.1 NZ_CP076592:2327693-2327968 [Erwinia amylovora]
MEIQWTQKAQDDLERIYRFACQYSRQHADNVLERLLIGTSGLADHPRIGVSQIRYEPREVRKILFDDYDVHYEIQRDTIY
IVDLWHTREDR
MEIQWTQKAQDDLERIYRFACQYSRQHADNVLERLLIGTSGLADHPRIGVSQIRYEPREVRKILFDDYDVHYEIQRDTIY
IVDLWHTREDR
Download Length: 276 bp
>T205997 NZ_CP102061:c2609639-2609532 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
Antitoxin
Download Length: 83 a.a. Molecular weight: 9121.53 Da Isoelectric Point: 8.7560
>AT205997 WP_004155191.1 NZ_CP076592:2327441-2327689 [Erwinia amylovora]
MRQLAKQTISAQIPAELAAAVENLAIELDRSKSWVIKEALTAMIEERERRHQQILKGLADVDAGRVVSHADVVDFANKLK
KS
MRQLAKQTISAQIPAELAAAVENLAIELDRSKSWVIKEALTAMIEERERRHQQILKGLADVDAGRVVSHADVVDFANKLK
KS
Download Length: 249 bp
>AT205997 NZ_CP102061:2609688-2609753 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A831EQZ9 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A831A0W7 |