Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 471522..472049 Replicon chromosome
Accession NZ_CP066794
Organism Erwinia amylovora strain 17-2187

Toxin (Protein)


Gene name relE Uniprot ID D4HV72
Locus tag JGC41_RS02190 Protein ID WP_004155192.1
Coordinates 471774..472049 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D4HV71
Locus tag JGC41_RS02185 Protein ID WP_004155191.1
Coordinates 471522..471770 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGC41_RS02150 466797..466994 - 198 WP_004155182.1 AlpA family phage regulatory protein -
JGC41_RS02155 468204..468446 + 243 WP_004155184.1 hypothetical protein -
JGC41_RS02160 468671..469245 + 575 Protein_422 DUF932 domain-containing protein -
JGC41_RS02165 469316..469786 + 471 WP_004155187.1 DNA repair protein RadC -
JGC41_RS02170 469799..470122 + 324 WP_004155188.1 type IV toxin-antitoxin system YeeU family antitoxin -
JGC41_RS02175 470159..470479 + 321 WP_004155189.1 TA system toxin CbtA family protein -
JGC41_RS02180 470592..471425 + 834 WP_004155190.1 DUF4942 domain-containing protein -
JGC41_RS02185 471522..471770 + 249 WP_004155191.1 ribbon-helix-helix domain-containing protein Antitoxin
JGC41_RS02190 471774..472049 + 276 WP_004155192.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JGC41_RS02195 472468..472668 + 201 Protein_429 transposase -
JGC41_RS02200 472664..472816 + 153 WP_004163933.1 hypothetical protein -
JGC41_RS02205 472965..476330 - 3366 WP_004155194.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 448878..472816 23938
flank IS/Tn - - 472468..472692 224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 11108.44 Da        Isoelectric Point: 5.5782

>T185028 WP_004155192.1 NZ_CP066794:471774-472049 [Erwinia amylovora]
MEIQWTQKAQDDLERIYRFACQYSRQHADNVLERLLIGTSGLADHPRIGVSQIRYEPREVRKILFDDYDVHYEIQRDTIY
IVDLWHTREDR

Download         Length: 276 bp

>T185028 NZ_CP087880:2101715-2102020 [Pseudocitrobacter corydidari]
ATGCCGCAAAAATTATTCAACATTGGAAGTTTTCGGGATCGTTGGCTAGCCGACTTTTTTAACTACGCGGCCCCGCACAA
ATTAATCCCAGGCGAAATTCATTCCGGGCTGGCTCGCAAACTCGATATCATCAACGCGGCTACCTGCTGGCAGGATCTCA
AGTCACCTCCGGGAAATCGTTACGAGCGGCTTCAGGGGAAACTTAAGGGTTATTCTTCTATCAGAGTGAACAAGCAGTAT
CGTGTAATTTTCAAATGGACTGATGGCAAGGCATACGATCTTTACCTCGATCCTCATGAATATTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9121.53 Da        Isoelectric Point: 8.7560

>AT185028 WP_004155191.1 NZ_CP066794:471522-471770 [Erwinia amylovora]
MRQLAKQTISAQIPAELAAAVENLAIELDRSKSWVIKEALTAMIEERERRHQQILKGLADVDAGRVVSHADVVDFANKLK
KS

Download         Length: 249 bp

>AT185028 NZ_CP087880:2102074-2102415 [Pseudocitrobacter corydidari]
ATGAACCAGGCAACCCGTAAACCGACCACTCCCGGTGATATCCTGCTGTATGAATTTCTGGAGCCGTTAAATCTTAAGAT
TAACGATCTTGCAGAGATGCTCCAGGTACACCGCAATACGGTCAGCGCGCTGGTCAATAACAACCGTAAGCTGACAACAG
ACATGGCCTTCAGGTTGGCGATTGTTTTTAATACTTCTGCTGAATTCTGGCTAAATCTGCAATCTGCCATCGATATCTGG
AAGATTGAAAACAATCCGCGTACTCAGCTTGAGTTGAGCCGCATCATCACGGCAGAGGACTTCATTGCTGCGCGTAAACA
ACAGGCGAAGGATGTTGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A831EQZ9

Antitoxin

Source ID Structure
AlphaFold DB A0A831A0W7

References