152398

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 3300067..3300594 Replicon chromosome
Accession NZ_CP050240
Organism Erwinia amylovora strain FB-20

Toxin (Protein)


Gene name relE Uniprot ID D4HV72
Locus tag EGZ89_RS14915 Protein ID WP_004155192.1
Coordinates 3300067..3300342 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D4HV71
Locus tag EGZ89_RS14920 Protein ID WP_004155191.1
Coordinates 3300346..3300594 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGZ89_RS14900 3295786..3299151 + 3366 WP_004155194.1 ATP-binding protein -
EGZ89_RS14905 3299300..3299452 - 153 WP_004163933.1 hypothetical protein -
EGZ89_RS14910 3299448..3299648 - 201 Protein_2872 transposase -
EGZ89_RS14915 3300067..3300342 - 276 WP_004155192.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EGZ89_RS14920 3300346..3300594 - 249 WP_004155191.1 ribbon-helix-helix domain-containing protein Antitoxin
EGZ89_RS14925 3300691..3301524 - 834 WP_004155190.1 DUF4942 domain-containing protein -
EGZ89_RS14930 3301637..3301957 - 321 WP_004155189.1 TA system toxin CbtA family protein -
EGZ89_RS14935 3301994..3302317 - 324 WP_004155188.1 type IV toxin-antitoxin system YeeU family antitoxin -
EGZ89_RS14940 3302330..3302800 - 471 WP_004155187.1 DNA repair protein RadC -
EGZ89_RS14945 3302871..3303445 - 575 Protein_2879 DUF932 domain-containing protein -
EGZ89_RS14950 3303670..3303912 - 243 WP_004155184.1 hypothetical protein -
EGZ89_RS14955 3305122..3305319 + 198 WP_004155182.1 AlpA family phage regulatory protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3299676..3323238 23562
flank IS/Tn - - 3299424..3299648 224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 11108.44 Da        Isoelectric Point: 5.5782

>T152398 WP_004155192.1 NZ_CP050240:c3300342-3300067 [Erwinia amylovora]
MEIQWTQKAQDDLERIYRFACQYSRQHADNVLERLLIGTSGLADHPRIGVSQIRYEPREVRKILFDDYDVHYEIQRDTIY
IVDLWHTREDR

Download         Length: 276 bp

>T152398 NZ_CP066144:c621934-621470 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGCGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAGCCATTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9121.53 Da        Isoelectric Point: 8.7560

>AT152398 WP_004155191.1 NZ_CP050240:c3300594-3300346 [Erwinia amylovora]
MRQLAKQTISAQIPAELAAAVENLAIELDRSKSWVIKEALTAMIEERERRHQQILKGLADVDAGRVVSHADVVDFANKLK
KS

Download         Length: 249 bp

>AT152398 NZ_CP066144:c622269-621934 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCTGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A831EQZ9

Antitoxin

Source ID Structure
AlphaFold DB A0A831A0W7

References