185037

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 469755..470435 Replicon chromosome
Accession NZ_CP066796
Organism Erwinia amylovora strain ATCC 15580

Toxin (Protein)


Gene name yeeV Uniprot ID D4HV69
Locus tag JGC47_RS02175 Protein ID WP_004155189.1
Coordinates 470115..470435 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID D4HV68
Locus tag JGC47_RS02170 Protein ID WP_004155188.1
Coordinates 469755..470078 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGC47_RS02140 464766..465851 - 1086 WP_004155179.1 DNA sulfur modification protein DndB -
JGC47_RS02145 466051..466645 - 595 Protein_419 hypothetical protein -
JGC47_RS02150 466753..466950 - 198 WP_004155182.1 AlpA family phage regulatory protein -
JGC47_RS02155 468160..468402 + 243 WP_004155184.1 hypothetical protein -
JGC47_RS02160 468627..469201 + 575 Protein_422 DUF932 domain-containing protein -
JGC47_RS02165 469272..469742 + 471 WP_004155187.1 DNA repair protein RadC -
JGC47_RS02170 469755..470078 + 324 WP_004155188.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JGC47_RS02175 470115..470435 + 321 WP_004155189.1 TA system toxin CbtA family protein Toxin
JGC47_RS02180 470548..471381 + 834 WP_004155190.1 DUF4942 domain-containing protein -
JGC47_RS02185 471478..471726 + 249 WP_004155191.1 ribbon-helix-helix domain-containing protein -
JGC47_RS02190 471730..472005 + 276 WP_004155192.1 type II toxin-antitoxin system RelE/ParE family toxin -
JGC47_RS02195 472424..472624 + 201 Protein_429 transposase -
JGC47_RS02200 472620..472772 + 153 WP_004163933.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 448854..472772 23918
flank IS/Tn - - 472424..472648 224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(5-105)

Antitoxin

Antitoxin CbeA

(7-106)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12023.69 Da        Isoelectric Point: 5.4732

>T185037 WP_004155189.1 NZ_CP066796:470115-470435 [Erwinia amylovora]
MHISTVPATVPVSSRLSPVQVWQQLLTYLLEHHYGLTLNDTPFHDDAAIEEHIDAGITLADAVNFLVERYELVRIDRKGF
TWQEQTPFLAATDILRARRATGLINI

Download         Length: 321 bp

>T185037 NZ_CP087880:3914515-3914826 [Pseudocitrobacter corydidari]
ATGATCTTCATCGAAACGGATTTTTTTACTGAAGATGTTCAAAAGCTACTGAATGACGATGAATACGGTCGTCTCCAGAT
TTTTCTCACATTGAATCCTCTTAATGGAGACGTCATTCCAGAAACGGGCGGTTTGCGGAAAATTCGGTGGGTAGCAGAGG
GAACAGGAAAGCGGGGCGGCGTGCGCGTCATTTATTACTATCGCGCTTCAGAGAGTGAGATCCGATTCCTTCTAATCTAT
AAAAAGGGAATTAAAGATGATCTTACCGCCCAGGAAAAGGCGATGCTACGAATGTTAAATGCGAGGTGGTAG

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12088.81 Da        Isoelectric Point: 6.4689

>AT185037 WP_004155188.1 NZ_CP066796:469755-470078 [Erwinia amylovora]
MSITLPHEWGLQSDITPRFGARLVQEGNRLYYLADRAGLTVSFSPIHLQKLDQAFPLFVEQLENMLRAGELNPHQQHQVT
IQLTSLTCIADTRGSCGYVYISIYPTP

Download         Length: 324 bp

>AT185037 NZ_CP087880:3914827-3915117 [Pseudocitrobacter corydidari]
ATGGATAAAGCGCTGTTCGAGCGGTTAGCCCAAAGCATGGCTCAAATGAATGAGATTGTTGCTGGTGAGCGTAAACCTTC
CAGGGTTTTTCACATTGATGCGCTTAAAATTAAAGAGATTCGTCACGCATCTGGTCTATCTCAATCTAAGTTTGCTGAAC
TGATATCCGTCAGTGTGGATACTCTGCGTAACTGGGAGCAAGGTCGCCGTTCGCCTACCGGGCCCGCGAAAGCATTGCTG
CGTGCAATTGCTAACGATCCACAGCATGTGATTCAGGCACTGAGTCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A831EPU6

Antitoxin

Source ID Structure
AlphaFold DB A0A831ENV6

References