Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 3117717..3118244 Replicon chromosome
Accession NZ_CP076594
Organism Erwinia amylovora isolate CP20086202

Toxin (Protein)


Gene name relE Uniprot ID D4HV72
Locus tag KQH36_RS14175 Protein ID WP_004155192.1
Coordinates 3117717..3117992 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D4HV71
Locus tag KQH36_RS14180 Protein ID WP_004155191.1
Coordinates 3117996..3118244 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQH36_RS14165 (KQH36_14155) 3113436..3116801 + 3366 WP_004155194.1 ATP-binding protein -
KQH36_RS14170 (KQH36_14165) 3117098..3117298 - 201 Protein_2739 transposase -
KQH36_RS14175 (KQH36_14170) 3117717..3117992 - 276 WP_004155192.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KQH36_RS14180 (KQH36_14175) 3117996..3118244 - 249 WP_004155191.1 ribbon-helix-helix domain-containing protein Antitoxin
KQH36_RS14185 (KQH36_14180) 3118341..3119174 - 834 WP_004155190.1 DUF4942 domain-containing protein -
KQH36_RS14190 (KQH36_14185) 3119287..3119607 - 321 WP_004155189.1 TA system toxin CbtA family protein -
KQH36_RS14195 (KQH36_14190) 3119644..3119967 - 324 WP_004155188.1 type IV toxin-antitoxin system YeeU family antitoxin -
KQH36_RS14200 (KQH36_14195) 3119980..3120450 - 471 WP_004155187.1 DNA repair protein RadC -
KQH36_RS14205 (KQH36_14200) 3120521..3121095 - 575 Protein_2746 DUF932 domain-containing protein -
KQH36_RS14210 (KQH36_14205) 3121320..3121562 - 243 WP_004155184.1 hypothetical protein -
KQH36_RS14215 (KQH36_14210) 3122772..3122969 + 198 WP_004155182.1 AlpA family phage regulatory protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3117326..3140888 23562
flank IS/Tn - - 3117074..3117298 224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 11108.44 Da        Isoelectric Point: 5.5782

>T206010 WP_004155192.1 NZ_CP076594:c3117992-3117717 [Erwinia amylovora]
MEIQWTQKAQDDLERIYRFACQYSRQHADNVLERLLIGTSGLADHPRIGVSQIRYEPREVRKILFDDYDVHYEIQRDTIY
IVDLWHTREDR

Download         Length: 276 bp

>T206010 NZ_CP102065:c1404921-1404058 [Enterococcus faecalis]
ATGGCAAATATAGTCAATTTTACTGACAAACAATTTGAGAATCGCTTAAATGATAATTTAGAAGAATTGATTCAAGGAAA
AAAAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGGAAAACCAGTTTGCGATCAGCAATTC
TTGAAGAAACACAAGGGAATGTTATTGTCATTGATAATGATACCTTTAAACAACAGCACCCTAATTTTGATGAACTAGCG
AAACTTTATGAGAAAGACGTAGTAAAACACGTCACCCCTTATTCTAATCGCATGACAGAAGCGATCATAAGCCGTTTGAG
CGATCAAGGCTATAATTTAGTGATTGAAGGTACAGGACGAACAACAGACGTTCCTATTCAAACCGCAACAATGCTTCAAG
CCAAAGGTTATGAAACAAAAATGTATGTTATGGCAGTACCTAAAATCAACTCATATTTAGGAACAATTGAACGATATGAA
ACTATGTATGCAGATGATCCAATGACAGCCAGGGCAACACCAAAACAAGCGCATGATATTGTTGTCAAAAACTTACCGAC
CAATTTAGAAACCCTTCATAAAACGGGCTTATTTAGCGATATAAGGCTTTACAATAGAGAAGGAGTGAAACTCTATTCAA
GATTAGAAACGCCTTCTATTAGTCCGAAAGAGACCTTAGAAAGAGAATTAAATCGTAAAGTATCAGGGAAAGAAATTCAA
CCGACTTTGGAGAGAATAGAGCAAAAAATGCTTCAAAATCAACACCAAGAAACCCCTGAATTTAAAGCAATTCAACAAAA
AATGGAAAGCTTGCAGCCACCTACACCACCAATACCCAAAACACCTAAACTTCCAGGACTTTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9121.53 Da        Isoelectric Point: 8.7560

>AT206010 WP_004155191.1 NZ_CP076594:c3118244-3117996 [Erwinia amylovora]
MRQLAKQTISAQIPAELAAAVENLAIELDRSKSWVIKEALTAMIEERERRHQQILKGLADVDAGRVVSHADVVDFANKLK
KS

Download         Length: 249 bp

>AT206010 NZ_CP102065:c1405195-1404923 [Enterococcus faecalis]
ATGGCAGTTACATATGAAAAAACATTTGAAATTGAAATCATTAATGAGTTATCGGCAAGTGTTTATAATCGAGTATTAAA
CTATGTTTTGAACCATGAATTAAATAAAAATGACTCTCAATTATTGGAAGTCAATTTATTAAACCAATTAAAGCTTGCAA
AACGTGTAAATCTTTTTGATTATTCTTTAGAAGAATTACAAGCCGTTCATGAGTATTGGCGGTCAATGAATCGTTACTCA
AAACAAGTTTTGAATAAAGAGAAAGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A831EQZ9

Antitoxin

Source ID Structure
AlphaFold DB A0A831A0W7

References