Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/RHH(antitoxin) |
Location | 3300332..3300859 | Replicon | chromosome |
Accession | NZ_CP050242 | ||
Organism | Erwinia amylovora strain FB-307 |
Toxin (Protein)
Gene name | relE | Uniprot ID | D4HV72 |
Locus tag | EHW99_RS14935 | Protein ID | WP_004155192.1 |
Coordinates | 3300332..3300607 (-) | Length | 92 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | D4HV71 |
Locus tag | EHW99_RS14940 | Protein ID | WP_004155191.1 |
Coordinates | 3300611..3300859 (-) | Length | 83 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
EHW99_RS14920 | 3296051..3299416 | + | 3366 | WP_004155194.1 | ATP-binding protein | - |
EHW99_RS14925 | 3299565..3299717 | - | 153 | WP_004163933.1 | hypothetical protein | - |
EHW99_RS14930 | 3299713..3299913 | - | 201 | Protein_2875 | transposase | - |
EHW99_RS14935 | 3300332..3300607 | - | 276 | WP_004155192.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
EHW99_RS14940 | 3300611..3300859 | - | 249 | WP_004155191.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
EHW99_RS14945 | 3300956..3301789 | - | 834 | WP_004155190.1 | DUF4942 domain-containing protein | - |
EHW99_RS14950 | 3301902..3302222 | - | 321 | WP_004155189.1 | TA system toxin CbtA family protein | - |
EHW99_RS14955 | 3302259..3302582 | - | 324 | WP_004155188.1 | type IV toxin-antitoxin system YeeU family antitoxin | - |
EHW99_RS14960 | 3302595..3303065 | - | 471 | WP_004155187.1 | DNA repair protein RadC | - |
EHW99_RS14965 | 3303136..3303710 | - | 575 | Protein_2882 | DUF932 domain-containing protein | - |
EHW99_RS14970 | 3303935..3304177 | - | 243 | WP_004155184.1 | hypothetical protein | - |
EHW99_RS14975 | 3305387..3305584 | + | 198 | WP_004155182.1 | AlpA family phage regulatory protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Genomic island | - | - | 3300332..3323509 | 23177 | ||
flank | IS/Tn | - | - | 3299689..3299913 | 224 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 11108.44 Da Isoelectric Point: 5.5782
>T152408 WP_004155192.1 NZ_CP050242:c3300607-3300332 [Erwinia amylovora]
MEIQWTQKAQDDLERIYRFACQYSRQHADNVLERLLIGTSGLADHPRIGVSQIRYEPREVRKILFDDYDVHYEIQRDTIY
IVDLWHTREDR
MEIQWTQKAQDDLERIYRFACQYSRQHADNVLERLLIGTSGLADHPRIGVSQIRYEPREVRKILFDDYDVHYEIQRDTIY
IVDLWHTREDR
Download Length: 276 bp
>T152408 NZ_CP066144:2833342-2833449 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCGTGATTTTCTGGCACGACCTGGCAGCACCGATCCTTGCGGGAATTATTACCGCAGCGAT
TGTTGGCTGGTGGCGTAGCCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCGTGATTTTCTGGCACGACCTGGCAGCACCGATCCTTGCGGGAATTATTACCGCAGCGAT
TGTTGGCTGGTGGCGTAGCCGGAAGTAA
Antitoxin
Download Length: 83 a.a. Molecular weight: 9121.53 Da Isoelectric Point: 8.7560
>AT152408 WP_004155191.1 NZ_CP050242:c3300859-3300611 [Erwinia amylovora]
MRQLAKQTISAQIPAELAAAVENLAIELDRSKSWVIKEALTAMIEERERRHQQILKGLADVDAGRVVSHADVVDFANKLK
KS
MRQLAKQTISAQIPAELAAAVENLAIELDRSKSWVIKEALTAMIEERERRHQQILKGLADVDAGRVVSHADVVDFANKLK
KS
Download Length: 249 bp
>AT152408 NZ_CP066144:c2833286-2833225 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTGACCTCTCAACGTGCGGGGGTTTTCT
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTGACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A831EQZ9 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A831A0W7 |