205963

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 594252..594779 Replicon chromosome
Accession NZ_CP076589
Organism Erwinia amylovora isolate CP201324

Toxin (Protein)


Gene name relE Uniprot ID D4HV72
Locus tag KQH38_RS02650 Protein ID WP_004155192.1
Coordinates 594504..594779 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D4HV71
Locus tag KQH38_RS02645 Protein ID WP_004155191.1
Coordinates 594252..594500 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQH38_RS02610 (KQH38_02615) 589527..589724 - 198 WP_004155182.1 AlpA family phage regulatory protein -
KQH38_RS02615 (KQH38_02620) 590934..591176 + 243 WP_004155184.1 hypothetical protein -
KQH38_RS02620 (KQH38_02625) 591401..591975 + 575 Protein_509 DUF932 domain-containing protein -
KQH38_RS02625 (KQH38_02630) 592046..592516 + 471 WP_004155187.1 DNA repair protein RadC -
KQH38_RS02630 (KQH38_02635) 592529..592852 + 324 WP_004155188.1 type IV toxin-antitoxin system YeeU family antitoxin -
KQH38_RS02635 (KQH38_02640) 592889..593209 + 321 WP_004155189.1 TA system toxin CbtA family protein -
KQH38_RS02640 (KQH38_02645) 593322..594155 + 834 WP_004155190.1 DUF4942 domain-containing protein -
KQH38_RS02645 (KQH38_02650) 594252..594500 + 249 WP_004155191.1 ribbon-helix-helix domain-containing protein Antitoxin
KQH38_RS02650 (KQH38_02655) 594504..594779 + 276 WP_004155192.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KQH38_RS02655 (KQH38_02660) 595198..595398 + 201 Protein_516 transposase -
KQH38_RS02660 (KQH38_02670) 595695..599060 - 3366 WP_004155194.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 571608..595546 23938
flank IS/Tn - - 595198..595422 224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 11108.44 Da        Isoelectric Point: 5.5782

>T205963 WP_004155192.1 NZ_CP076589:594504-594779 [Erwinia amylovora]
MEIQWTQKAQDDLERIYRFACQYSRQHADNVLERLLIGTSGLADHPRIGVSQIRYEPREVRKILFDDYDVHYEIQRDTIY
IVDLWHTREDR

Download         Length: 276 bp

>T205963 NZ_CP101940:3484065-3484340 [Salmonella enterica subsp. enterica]
ATGGGGCAAAGGAAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGGGCCTGACTGGATTCTTATTGATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9121.53 Da        Isoelectric Point: 8.7560

>AT205963 WP_004155191.1 NZ_CP076589:594252-594500 [Erwinia amylovora]
MRQLAKQTISAQIPAELAAAVENLAIELDRSKSWVIKEALTAMIEERERRHQQILKGLADVDAGRVVSHADVVDFANKLK
KS

Download         Length: 249 bp

>AT205963 NZ_CP101940:3483802-3484062 [Salmonella enterica subsp. enterica]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGAATCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGGATAC
CCAATGAGTTAACGTCCCGAACGATAGAAAATAGCGAAGCTGGCGTTGACATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A831EQZ9

Antitoxin

Source ID Structure
AlphaFold DB A0A831A0W7

References