205996

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2325718..2326398 Replicon chromosome
Accession NZ_CP076592
Organism Erwinia amylovora isolate CP20140001

Toxin (Protein)


Gene name yeeV Uniprot ID D4HV69
Locus tag KQH33_RS10390 Protein ID WP_004155189.1
Coordinates 2326078..2326398 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID D4HV68
Locus tag KQH33_RS10385 Protein ID WP_004155188.1
Coordinates 2325718..2326041 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQH33_RS10355 (KQH33_10380) 2320729..2321814 - 1086 WP_004155179.1 DNA sulfur modification protein DndB -
KQH33_RS10360 2322258..2322608 - 351 WP_004155181.1 hypothetical protein -
KQH33_RS10365 (KQH33_10390) 2322716..2322913 - 198 WP_004155182.1 AlpA family phage regulatory protein -
KQH33_RS10370 (KQH33_10395) 2324123..2324365 + 243 WP_004155184.1 hypothetical protein -
KQH33_RS10375 (KQH33_10400) 2324590..2325164 + 575 Protein_2002 DUF932 domain-containing protein -
KQH33_RS10380 (KQH33_10405) 2325235..2325705 + 471 WP_004155187.1 DNA repair protein RadC -
KQH33_RS10385 (KQH33_10410) 2325718..2326041 + 324 WP_004155188.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KQH33_RS10390 (KQH33_10415) 2326078..2326398 + 321 WP_004155189.1 TA system toxin CbtA family protein Toxin
KQH33_RS10395 (KQH33_10420) 2326511..2327344 + 834 WP_004155190.1 DUF4942 domain-containing protein -
KQH33_RS10400 (KQH33_10425) 2327441..2327689 + 249 WP_004155191.1 ribbon-helix-helix domain-containing protein -
KQH33_RS10405 (KQH33_10430) 2327693..2327968 + 276 WP_004155192.1 type II toxin-antitoxin system RelE/ParE family toxin -
KQH33_RS10410 (KQH33_10435) 2328387..2328587 + 201 Protein_2009 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2304797..2328735 23938
flank IS/Tn - - 2328387..2328611 224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(5-105)

Antitoxin

Antitoxin CbeA

(7-106)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12023.69 Da        Isoelectric Point: 5.4732

>T205996 WP_004155189.1 NZ_CP076592:2326078-2326398 [Erwinia amylovora]
MHISTVPATVPVSSRLSPVQVWQQLLTYLLEHHYGLTLNDTPFHDDAAIEEHIDAGITLADAVNFLVERYELVRIDRKGF
TWQEQTPFLAATDILRARRATGLINI

Download         Length: 321 bp

>T205996 NZ_CP102061:c2609156-2609049 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12088.81 Da        Isoelectric Point: 6.4689

>AT205996 WP_004155188.1 NZ_CP076592:2325718-2326041 [Erwinia amylovora]
MSITLPHEWGLQSDITPRFGARLVQEGNRLYYLADRAGLTVSFSPIHLQKLDQAFPLFVEQLENMLRAGELNPHQQHQVT
IQLTSLTCIADTRGSCGYVYISIYPTP

Download         Length: 324 bp

>AT205996 NZ_CP102061:2609213-2609270 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A831EPU6

Antitoxin

Source ID Structure
AlphaFold DB A0A831ENV6

References