Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 3297203..3297730 Replicon chromosome
Accession NZ_CP104022
Organism Erwinia amylovora strain Ea102

Toxin (Protein)


Gene name relE Uniprot ID D4HV72
Locus tag MTP49_RS14935 Protein ID WP_004155192.1
Coordinates 3297203..3297478 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D4HV71
Locus tag MTP49_RS14940 Protein ID WP_004155191.1
Coordinates 3297482..3297730 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTP49_RS14925 (MTP49_14925) 3292922..3296287 + 3366 WP_004155194.1 ATP-binding protein -
MTP49_RS14930 (MTP49_14930) 3296584..3296784 - 201 Protein_2875 transposase -
MTP49_RS14935 (MTP49_14935) 3297203..3297478 - 276 WP_004155192.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MTP49_RS14940 (MTP49_14940) 3297482..3297730 - 249 WP_004155191.1 ribbon-helix-helix domain-containing protein Antitoxin
MTP49_RS14945 (MTP49_14945) 3297827..3298660 - 834 WP_004155190.1 DUF4942 domain-containing protein -
MTP49_RS14950 (MTP49_14950) 3298773..3299093 - 321 WP_004155189.1 TA system toxin CbtA family protein -
MTP49_RS14955 (MTP49_14955) 3299130..3299453 - 324 WP_004155188.1 type IV toxin-antitoxin system YeeU family antitoxin -
MTP49_RS14960 (MTP49_14960) 3299466..3299936 - 471 WP_004155187.1 DNA repair protein RadC -
MTP49_RS14965 (MTP49_14965) 3300007..3300581 - 575 Protein_2882 DUF945 domain-containing protein -
MTP49_RS14970 (MTP49_14970) 3300806..3301048 - 243 WP_004155184.1 hypothetical protein -
MTP49_RS14975 (MTP49_14975) 3302258..3302455 + 198 WP_004155182.1 AlpA family phage regulatory protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3297203..3320361 23158
flank IS/Tn - - 3296560..3296784 224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 11108.44 Da        Isoelectric Point: 5.5782

>T257031 WP_004155192.1 NZ_CP104022:c3297478-3297203 [Erwinia amylovora]
MEIQWTQKAQDDLERIYRFACQYSRQHADNVLERLLIGTSGLADHPRIGVSQIRYEPREVRKILFDDYDVHYEIQRDTIY
IVDLWHTREDR

Download         Length: 276 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9121.53 Da        Isoelectric Point: 8.7560

>AT257031 WP_004155191.1 NZ_CP104022:c3297730-3297482 [Erwinia amylovora]
MRQLAKQTISAQIPAELAAAVENLAIELDRSKSWVIKEALTAMIEERERRHQQILKGLADVDAGRVVSHADVVDFANKLK
KS

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A831EQZ9

Antitoxin

Source ID Structure
AlphaFold DB A0A831A0W7

References