271322

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 471477..472004 Replicon chromosome
Accession NZ_CP117554
Organism Erwinia amylovora strain 99east-3-1

Toxin (Protein)


Gene name relE Uniprot ID D4HV72
Locus tag PTC76_RS02180 Protein ID WP_004155192.1
Coordinates 471729..472004 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D4HV71
Locus tag PTC76_RS02175 Protein ID WP_004155191.1
Coordinates 471477..471725 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC76_RS02140 (PTC76_02140) 466752..466949 - 198 WP_004155182.1 AlpA family phage regulatory protein -
PTC76_RS02145 (PTC76_02145) 468159..468401 + 243 WP_004155184.1 hypothetical protein -
PTC76_RS02150 (PTC76_02150) 468626..469200 + 575 Protein_420 DUF932 domain-containing protein -
PTC76_RS02155 (PTC76_02155) 469271..469741 + 471 WP_004155187.1 DNA repair protein RadC -
PTC76_RS02160 (PTC76_02160) 469754..470077 + 324 WP_004155188.1 type IV toxin-antitoxin system YeeU family antitoxin -
PTC76_RS02165 (PTC76_02165) 470114..470434 + 321 WP_004155189.1 TA system toxin CbtA family protein -
PTC76_RS02170 (PTC76_02170) 470547..471380 + 834 WP_004155190.1 DUF4942 domain-containing protein -
PTC76_RS02175 (PTC76_02175) 471477..471725 + 249 WP_004155191.1 ribbon-helix-helix domain-containing protein Antitoxin
PTC76_RS02180 (PTC76_02180) 471729..472004 + 276 WP_004155192.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PTC76_RS02185 (PTC76_02185) 472423..472623 + 201 Protein_427 transposase -
PTC76_RS02190 (PTC76_02190) 472920..476285 - 3366 WP_004155194.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 448846..472771 23925
flank IS/Tn - - 472423..472647 224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 11108.44 Da        Isoelectric Point: 5.5782

>T271322 WP_004155192.1 NZ_CP117554:471729-472004 [Erwinia amylovora]
MEIQWTQKAQDDLERIYRFACQYSRQHADNVLERLLIGTSGLADHPRIGVSQIRYEPREVRKILFDDYDVHYEIQRDTIY
IVDLWHTREDR

Download         Length: 276 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9121.53 Da        Isoelectric Point: 8.7560

>AT271322 WP_004155191.1 NZ_CP117554:471477-471725 [Erwinia amylovora]
MRQLAKQTISAQIPAELAAAVENLAIELDRSKSWVIKEALTAMIEERERRHQQILKGLADVDAGRVVSHADVVDFANKLK
KS

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A831EQZ9

Antitoxin

Source ID Structure
AlphaFold DB A0A831A0W7

References