Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
Location | 470219..470899 | Replicon | chromosome |
Accession | NZ_CP064855 | ||
Organism | Erwinia amylovora strain Ea1/79Sm |
Toxin (Protein)
Gene name | yeeV | Uniprot ID | D4HV69 |
Locus tag | IYV53_RS02170 | Protein ID | WP_004155189.1 |
Coordinates | 470579..470899 (+) | Length | 107 a.a. |
Antitoxin (Protein)
Gene name | yeeU | Uniprot ID | D4HV68 |
Locus tag | IYV53_RS02165 | Protein ID | WP_004155188.1 |
Coordinates | 470219..470542 (+) | Length | 108 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
IYV53_RS02135 | 465230..466315 | - | 1086 | WP_004155179.1 | DNA sulfur modification protein DndB | - |
IYV53_RS02140 | 466515..467109 | - | 595 | Protein_418 | hypothetical protein | - |
IYV53_RS02145 | 467217..467414 | - | 198 | WP_004155182.1 | AlpA family phage regulatory protein | - |
IYV53_RS02150 | 468624..468866 | + | 243 | WP_004155184.1 | hypothetical protein | - |
IYV53_RS02155 | 469091..469665 | + | 575 | Protein_421 | DUF932 domain-containing protein | - |
IYV53_RS02160 | 469736..470206 | + | 471 | WP_004155187.1 | DNA repair protein RadC | - |
IYV53_RS02165 | 470219..470542 | + | 324 | WP_004155188.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
IYV53_RS02170 | 470579..470899 | + | 321 | WP_004155189.1 | TA system toxin CbtA family protein | Toxin |
IYV53_RS02175 | 471012..471845 | + | 834 | WP_004155190.1 | DUF4942 domain-containing protein | - |
IYV53_RS02180 | 471942..472190 | + | 249 | WP_004155191.1 | ribbon-helix-helix domain-containing protein | - |
IYV53_RS02185 | 472194..472469 | + | 276 | WP_004155192.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
IYV53_RS02190 | 472888..473088 | + | 201 | Protein_428 | transposase | - |
IYV53_RS02195 | 473084..473236 | + | 153 | WP_004163933.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Genomic island | - | - | 449316..473236 | 23920 | ||
flank | IS/Tn | - | - | 472888..473112 | 224 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 107 a.a. Molecular weight: 12023.69 Da Isoelectric Point: 5.4732
>T181838 WP_004155189.1 NZ_CP064855:470579-470899 [Erwinia amylovora]
MHISTVPATVPVSSRLSPVQVWQQLLTYLLEHHYGLTLNDTPFHDDAAIEEHIDAGITLADAVNFLVERYELVRIDRKGF
TWQEQTPFLAATDILRARRATGLINI
MHISTVPATVPVSSRLSPVQVWQQLLTYLLEHHYGLTLNDTPFHDDAAIEEHIDAGITLADAVNFLVERYELVRIDRKGF
TWQEQTPFLAATDILRARRATGLINI
Download Length: 321 bp
>T181838 NZ_CP086183:c4779202-4779068 [Xanthomonas oryzae]
ATGAAGCGTGCAATTGTGCTGCTCGTGCTGTCCATGTTGTCGGTCGGTCTGCTGTCGGGCTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGAAGGGCGCCGGCGAGAAGGTGGAAGACGCAGCGCGTAAGTAA
ATGAAGCGTGCAATTGTGCTGCTCGTGCTGTCCATGTTGTCGGTCGGTCTGCTGTCGGGCTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGAAGGGCGCCGGCGAGAAGGTGGAAGACGCAGCGCGTAAGTAA
Antitoxin
Download Length: 108 a.a. Molecular weight: 12088.81 Da Isoelectric Point: 6.4689
>AT181838 WP_004155188.1 NZ_CP064855:470219-470542 [Erwinia amylovora]
MSITLPHEWGLQSDITPRFGARLVQEGNRLYYLADRAGLTVSFSPIHLQKLDQAFPLFVEQLENMLRAGELNPHQQHQVT
IQLTSLTCIADTRGSCGYVYISIYPTP
MSITLPHEWGLQSDITPRFGARLVQEGNRLYYLADRAGLTVSFSPIHLQKLDQAFPLFVEQLENMLRAGELNPHQQHQVT
IQLTSLTCIADTRGSCGYVYISIYPTP
Download Length: 324 bp
>AT181838 NZ_CP086183:c4779418-4779266 [Xanthomonas oryzae]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGGCCGGCGTGATGACGGGCTGCAACACCGTGGCTGGCGC
TGGCAAGGACTTGCAGGGCGCGGGTGGGAAGGTCGAGAAAACGGCCGAAAAATGCAGCGATGGTAAGTGCTGA
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGGCCGGCGTGATGACGGGCTGCAACACCGTGGCTGGCGC
TGGCAAGGACTTGCAGGGCGCGGGTGGGAAGGTCGAGAAAACGGCCGAAAAATGCAGCGATGGTAAGTGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A831EPU6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A831ENV6 |