Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 468423..468950 Replicon chromosome
Accession NC_013961
Organism Erwinia amylovora CFBP1430

Toxin (Protein)


Gene name relE Uniprot ID D4HV72
Locus tag EAMY_RS19320 Protein ID WP_004155192.1
Coordinates 468675..468950 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D4HV71
Locus tag EAMY_RS19315 Protein ID WP_004155191.1
Coordinates 468423..468671 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EAMY_RS19280 463698..463895 - 198 WP_004155182.1 AlpA family phage regulatory protein -
EAMY_RS34675 465105..465347 + 243 WP_004155184.1 hypothetical protein -
EAMY_RS34680 465572..466146 + 575 Protein_374 DUF932 domain-containing protein -
EAMY_RS19295 466217..466687 + 471 WP_004155187.1 DNA repair protein RadC -
EAMY_RS19300 466700..467023 + 324 WP_004155188.1 type IV toxin-antitoxin system YeeU family antitoxin -
EAMY_RS19305 467060..467380 + 321 WP_004155189.1 TA system toxin CbtA family protein -
EAMY_RS19310 467493..468326 + 834 WP_004155190.1 DUF4942 domain-containing protein -
EAMY_RS19315 468423..468671 + 249 WP_004155191.1 ribbon-helix-helix domain-containing protein Antitoxin
EAMY_RS19320 468675..468950 + 276 WP_004155192.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EAMY_RS19325 469369..469569 + 201 Protein_381 transposase -
EAMY_RS36140 469565..469717 + 153 WP_004163933.1 hypothetical protein -
EAMY_RS19330 469866..473231 - 3366 WP_004155194.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 445798..469717 23919
flank IS/Tn - - 469369..469593 224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 11108.44 Da        Isoelectric Point: 5.5782

>T24674 WP_004155192.1 NC_013961:468675-468950 [Erwinia amylovora CFBP1430]
MEIQWTQKAQDDLERIYRFACQYSRQHADNVLERLLIGTSGLADHPRIGVSQIRYEPREVRKILFDDYDVHYEIQRDTIY
IVDLWHTREDR

Download         Length: 276 bp

>T24674 NC_013961:468675-468950 [Erwinia amylovora CFBP1430]
ATGGAAATACAGTGGACCCAAAAGGCCCAGGATGACCTGGAGCGTATTTATAGGTTTGCCTGTCAGTACAGTCGGCAACA
TGCTGACAACGTATTAGAGCGTTTGCTCATAGGAACCTCAGGGCTCGCCGACCATCCAAGAATCGGTGTTTCTCAGATAA
GATATGAACCACGAGAAGTGAGAAAAATCTTGTTTGATGATTATGACGTTCACTATGAAATTCAGCGCGACACTATCTAT
ATTGTTGACCTTTGGCATACCCGAGAGGATCGCTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9121.53 Da        Isoelectric Point: 8.7560

>AT24674 WP_004155191.1 NC_013961:468423-468671 [Erwinia amylovora CFBP1430]
MRQLAKQTISAQIPAELAAAVENLAIELDRSKSWVIKEALTAMIEERERRHQQILKGLADVDAGRVVSHADVVDFANKLK
KS

Download         Length: 249 bp

>AT24674 NC_013961:468423-468671 [Erwinia amylovora CFBP1430]
ATGAGACAACTCGCGAAACAGACGATCAGCGCTCAGATCCCTGCAGAGCTTGCCGCGGCGGTTGAAAACCTGGCTATTGA
ACTGGACAGATCTAAAAGCTGGGTGATTAAAGAAGCGCTGACCGCCATGATTGAAGAGAGAGAGCGGCGGCATCAGCAGA
TTTTGAAAGGGCTTGCTGATGTCGATGCGGGAAGAGTGGTTAGCCATGCGGATGTAGTTGACTTCGCTAACAAACTGAAA
AAATCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A831EQZ9

Antitoxin

Source ID Structure
AlphaFold DB A0A831A0W7

References