152434

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3302110..3302790 Replicon chromosome
Accession NZ_CP050258
Organism Erwinia amylovora strain FB-86

Toxin (Protein)


Gene name yeeV Uniprot ID D4HV69
Locus tag EHW96_RS14930 Protein ID WP_004155189.1
Coordinates 3302110..3302430 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID D4HV68
Locus tag EHW96_RS14935 Protein ID WP_004155188.1
Coordinates 3302467..3302790 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EHW96_RS14905 3299773..3299925 - 153 WP_004163933.1 hypothetical protein -
EHW96_RS14910 3299921..3300121 - 201 Protein_2871 transposase -
EHW96_RS14915 3300540..3300815 - 276 WP_004155192.1 type II toxin-antitoxin system RelE/ParE family toxin -
EHW96_RS14920 3300819..3301067 - 249 WP_004155191.1 ribbon-helix-helix domain-containing protein -
EHW96_RS14925 3301164..3301997 - 834 WP_004155190.1 DUF4942 domain-containing protein -
EHW96_RS14930 3302110..3302430 - 321 WP_004155189.1 TA system toxin CbtA family protein Toxin
EHW96_RS14935 3302467..3302790 - 324 WP_004155188.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EHW96_RS14940 3302803..3303273 - 471 WP_004155187.1 DNA repair protein RadC -
EHW96_RS14945 3303344..3303918 - 575 Protein_2878 DUF932 domain-containing protein -
EHW96_RS14950 3304143..3304385 - 243 WP_004155184.1 hypothetical protein -
EHW96_RS14955 3305595..3305792 + 198 WP_004155182.1 AlpA family phage regulatory protein -
EHW96_RS14960 3305900..3306494 + 595 Protein_2881 hypothetical protein -
EHW96_RS14965 3306694..3307779 + 1086 WP_004155179.1 DNA sulfur modification protein DndB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3300540..3323711 23171
flank IS/Tn - - 3299897..3300121 224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(5-105)

Antitoxin

Antitoxin CbeA

(7-106)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12023.69 Da        Isoelectric Point: 5.4732

>T152434 WP_004155189.1 NZ_CP050258:c3302430-3302110 [Erwinia amylovora]
MHISTVPATVPVSSRLSPVQVWQQLLTYLLEHHYGLTLNDTPFHDDAAIEEHIDAGITLADAVNFLVERYELVRIDRKGF
TWQEQTPFLAATDILRARRATGLINI

Download         Length: 321 bp

>T152434 NZ_CP066151:4210209-4210427 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12088.81 Da        Isoelectric Point: 6.4689

>AT152434 WP_004155188.1 NZ_CP050258:c3302790-3302467 [Erwinia amylovora]
MSITLPHEWGLQSDITPRFGARLVQEGNRLYYLADRAGLTVSFSPIHLQKLDQAFPLFVEQLENMLRAGELNPHQQHQVT
IQLTSLTCIADTRGSCGYVYISIYPTP

Download         Length: 324 bp

>AT152434 NZ_CP066151:4209808-4210182 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A831EPU6

Antitoxin

Source ID Structure
AlphaFold DB A0A831ENV6

References