185038

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 471478..472005 Replicon chromosome
Accession NZ_CP066796
Organism Erwinia amylovora strain ATCC 15580

Toxin (Protein)


Gene name relE Uniprot ID D4HV72
Locus tag JGC47_RS02190 Protein ID WP_004155192.1
Coordinates 471730..472005 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D4HV71
Locus tag JGC47_RS02185 Protein ID WP_004155191.1
Coordinates 471478..471726 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGC47_RS02150 466753..466950 - 198 WP_004155182.1 AlpA family phage regulatory protein -
JGC47_RS02155 468160..468402 + 243 WP_004155184.1 hypothetical protein -
JGC47_RS02160 468627..469201 + 575 Protein_422 DUF932 domain-containing protein -
JGC47_RS02165 469272..469742 + 471 WP_004155187.1 DNA repair protein RadC -
JGC47_RS02170 469755..470078 + 324 WP_004155188.1 type IV toxin-antitoxin system YeeU family antitoxin -
JGC47_RS02175 470115..470435 + 321 WP_004155189.1 TA system toxin CbtA family protein -
JGC47_RS02180 470548..471381 + 834 WP_004155190.1 DUF4942 domain-containing protein -
JGC47_RS02185 471478..471726 + 249 WP_004155191.1 ribbon-helix-helix domain-containing protein Antitoxin
JGC47_RS02190 471730..472005 + 276 WP_004155192.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JGC47_RS02195 472424..472624 + 201 Protein_429 transposase -
JGC47_RS02200 472620..472772 + 153 WP_004163933.1 hypothetical protein -
JGC47_RS02205 472921..476286 - 3366 WP_004155194.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 448854..472772 23918
flank IS/Tn - - 472424..472648 224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 11108.44 Da        Isoelectric Point: 5.5782

>T185038 WP_004155192.1 NZ_CP066796:471730-472005 [Erwinia amylovora]
MEIQWTQKAQDDLERIYRFACQYSRQHADNVLERLLIGTSGLADHPRIGVSQIRYEPREVRKILFDDYDVHYEIQRDTIY
IVDLWHTREDR

Download         Length: 276 bp

>T185038 NZ_CP087880:3915873-3916247 [Pseudocitrobacter corydidari]
ATGACTAATGGATCGGCACTTTTTGACACCAATATTTTAATCGATCTATTCAGTGGGCGACGCGAGGCAAAACAAGCGCT
AGATGCCTGGCCGCCGCAGAATGCGATTAGTATCGTCACGTGGATGGAAGTGATGGTTGGTGCCAAAAAGTATAATCAAG
AGCACCGTACGCGCGTTGCGATGAGCGCTTTTAATATTATTGGGGTATCGCAGGCGATAGCCGAGCGAAGCGTTGCTTTA
AGGCAAGAGTATGGGATGAAACTTCCGGATGCGATTATTCTGGCGACCGCGCAGGTTCATCGTCTCGAACTGGTCACCAG
AAATACTAAAGACTTTAAAGATATCGTGGGCGTTGTAACACCCTATGAACTGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9121.53 Da        Isoelectric Point: 8.7560

>AT185038 WP_004155191.1 NZ_CP066796:471478-471726 [Erwinia amylovora]
MRQLAKQTISAQIPAELAAAVENLAIELDRSKSWVIKEALTAMIEERERRHQQILKGLADVDAGRVVSHADVVDFANKLK
KS

Download         Length: 249 bp

>AT185038 NZ_CP087880:3915631-3915873 [Pseudocitrobacter corydidari]
ATGAGCGTGATGATTGGGCTGGATATGGGCAGAATTTTACTCGATTTATCAGATGAAGTGATTAAACGACTGGACGATCT
CAAAGTGCAGCGCAACCTTCCACGCGCAGAACTATTGCGAGAGGCCGTAGAGCAGTATCTGGAAAGGCAGTCAAATACAA
CTATTTCCAATGCACTCGGCCTGTGGCAGGGATGTGAAGAAGATGGTGTTGAATACCAGCGCAAGCTTCGTGAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A831EQZ9

Antitoxin

Source ID Structure
AlphaFold DB A0A831A0W7

References