Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 3300539..3301066 Replicon chromosome
Accession NZ_CP050244
Organism Erwinia amylovora strain TS3238

Toxin (Protein)


Gene name relE Uniprot ID D4HV72
Locus tag EHX00_RS14910 Protein ID WP_004155192.1
Coordinates 3300539..3300814 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D4HV71
Locus tag EHX00_RS14915 Protein ID WP_004155191.1
Coordinates 3300818..3301066 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EHX00_RS14895 3296258..3299623 + 3366 WP_004155194.1 ATP-binding protein -
EHX00_RS14900 3299772..3299924 - 153 WP_004163933.1 hypothetical protein -
EHX00_RS14905 3299920..3300120 - 201 Protein_2870 transposase -
EHX00_RS14910 3300539..3300814 - 276 WP_004155192.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EHX00_RS14915 3300818..3301066 - 249 WP_004155191.1 ribbon-helix-helix domain-containing protein Antitoxin
EHX00_RS14920 3301163..3301996 - 834 WP_004155190.1 DUF4942 domain-containing protein -
EHX00_RS14925 3302109..3302429 - 321 WP_004155189.1 TA system toxin CbtA family protein -
EHX00_RS14930 3302466..3302789 - 324 WP_004155188.1 type IV toxin-antitoxin system YeeU family antitoxin -
EHX00_RS14935 3302802..3303272 - 471 WP_004155187.1 DNA repair protein RadC -
EHX00_RS14940 3303343..3303917 - 575 Protein_2877 DUF932 domain-containing protein -
EHX00_RS14945 3304142..3304384 - 243 WP_004155184.1 hypothetical protein -
EHX00_RS14950 3305594..3305791 + 198 WP_004155182.1 AlpA family phage regulatory protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3300539..3323710 23171
flank IS/Tn - - 3299896..3300120 224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 11108.44 Da        Isoelectric Point: 5.5782

>T152418 WP_004155192.1 NZ_CP050244:c3300814-3300539 [Erwinia amylovora]
MEIQWTQKAQDDLERIYRFACQYSRQHADNVLERLLIGTSGLADHPRIGVSQIRYEPREVRKILFDDYDVHYEIQRDTIY
IVDLWHTREDR

Download         Length: 276 bp

>T152418 NZ_CP066144:c4608219-4608046 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTTCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9121.53 Da        Isoelectric Point: 8.7560

>AT152418 WP_004155191.1 NZ_CP050244:c3301066-3300818 [Erwinia amylovora]
MRQLAKQTISAQIPAELAAAVENLAIELDRSKSWVIKEALTAMIEERERRHQQILKGLADVDAGRVVSHADVVDFANKLK
KS

Download         Length: 249 bp

>AT152418 NZ_CP066144:c4608543-4608247 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAACTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A831EQZ9

Antitoxin

Source ID Structure
AlphaFold DB A0A831A0W7

References