271321

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 469754..470434 Replicon chromosome
Accession NZ_CP117554
Organism Erwinia amylovora strain 99east-3-1

Toxin (Protein)


Gene name yeeV Uniprot ID D4HV69
Locus tag PTC76_RS02165 Protein ID WP_004155189.1
Coordinates 470114..470434 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID D4HV68
Locus tag PTC76_RS02160 Protein ID WP_004155188.1
Coordinates 469754..470077 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC76_RS02130 (PTC76_02130) 464765..465850 - 1086 WP_004155179.1 DNA sulfur modification protein DndB -
PTC76_RS02135 (PTC76_02135) 466294..466644 - 351 WP_004155181.1 hypothetical protein -
PTC76_RS02140 (PTC76_02140) 466752..466949 - 198 WP_004155182.1 AlpA family phage regulatory protein -
PTC76_RS02145 (PTC76_02145) 468159..468401 + 243 WP_004155184.1 hypothetical protein -
PTC76_RS02150 (PTC76_02150) 468626..469200 + 575 Protein_420 DUF932 domain-containing protein -
PTC76_RS02155 (PTC76_02155) 469271..469741 + 471 WP_004155187.1 DNA repair protein RadC -
PTC76_RS02160 (PTC76_02160) 469754..470077 + 324 WP_004155188.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
PTC76_RS02165 (PTC76_02165) 470114..470434 + 321 WP_004155189.1 TA system toxin CbtA family protein Toxin
PTC76_RS02170 (PTC76_02170) 470547..471380 + 834 WP_004155190.1 DUF4942 domain-containing protein -
PTC76_RS02175 (PTC76_02175) 471477..471725 + 249 WP_004155191.1 ribbon-helix-helix domain-containing protein -
PTC76_RS02180 (PTC76_02180) 471729..472004 + 276 WP_004155192.1 type II toxin-antitoxin system RelE/ParE family toxin -
PTC76_RS02185 (PTC76_02185) 472423..472623 + 201 Protein_427 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 448846..472771 23925
flank IS/Tn - - 472423..472647 224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(5-105)

Antitoxin

Antitoxin CbeA

(7-106)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12023.69 Da        Isoelectric Point: 5.4732

>T271321 WP_004155189.1 NZ_CP117554:470114-470434 [Erwinia amylovora]
MHISTVPATVPVSSRLSPVQVWQQLLTYLLEHHYGLTLNDTPFHDDAAIEEHIDAGITLADAVNFLVERYELVRIDRKGF
TWQEQTPFLAATDILRARRATGLINI

Download         Length: 321 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12088.81 Da        Isoelectric Point: 6.4689

>AT271321 WP_004155188.1 NZ_CP117554:469754-470077 [Erwinia amylovora]
MSITLPHEWGLQSDITPRFGARLVQEGNRLYYLADRAGLTVSFSPIHLQKLDQAFPLFVEQLENMLRAGELNPHQQHQVT
IQLTSLTCIADTRGSCGYVYISIYPTP

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A831EPU6

Antitoxin

Source ID Structure
AlphaFold DB A0A831ENV6

References