Detailed information of TA system TA185027

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 469799..470479
• Replicon: chromosome
• Accession: NZ_CP066794
• Organism: Erwinia amylovora strain 17-2187

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: D4HV69
• Locus tag: JGC41_RS02175
• Protein ID: WP_004155189.1
• Coordinates: 470159..470479 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: D4HV68
• Locus tag: JGC41_RS02170
• Protein ID: WP_004155188.1
• Coordinates: 469799..470122 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JGC41_RS02140	464810..465895	-	1086	WP_004155179.1	DNA sulfur modification protein DndB	-
JGC41_RS02145	466095..466689	-	595	Protein_419	hypothetical protein	-
JGC41_RS02150	466797..466994	-	198	WP_004155182.1	AlpA family phage regulatory protein	-
JGC41_RS02155	468204..468446	+	243	WP_004155184.1	hypothetical protein	-
JGC41_RS02160	468671..469245	+	575	Protein_422	DUF932 domain-containing protein	-
JGC41_RS02165	469316..469786	+	471	WP_004155187.1	DNA repair protein RadC	-
JGC41_RS02170	469799..470122	+	324	WP_004155188.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
JGC41_RS02175	470159..470479	+	321	WP_004155189.1	TA system toxin CbtA family protein	Toxin
JGC41_RS02180	470592..471425	+	834	WP_004155190.1	DUF4942 domain-containing protein	-
JGC41_RS02185	471522..471770	+	249	WP_004155191.1	ribbon-helix-helix domain-containing protein	-
JGC41_RS02190	471774..472049	+	276	WP_004155192.1	type II toxin-antitoxin system RelE/ParE family toxin	-
JGC41_RS02195	472468..472668	+	201	Protein_429	transposase	-
JGC41_RS02200	472664..472816	+	153	WP_004163933.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_013971 Erwinia amylovora ATCC 49946 Genomic island TA024692 3302629..3325491 0.001 View NZ_NQJO01000001 Erwinia amylovora strain CTBT3-1 tig00000000 Genomic island TA010128, TA294492 3404618..3427747 0.001	inside	Genomic island	-	-	448878..472816	23938
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_013971 Erwinia amylovora ATCC 49946 IS/Tn TA024691, TA024692 3301707..3301931 0 View NZ_NQJO01000001 Erwinia amylovora strain CTBT3-1 tig00000000 IS/Tn TA010128, TA294492 3403975..3404199 0	flank	IS/Tn	-	-	472468..472692	224

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (5-105)

Antitoxin

• Antitoxin CbeA (7-106)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12023.69 Da
• Isoelectric Point: 5.4732

>T185027 WP_004155189.1 NZ_CP066794:470159-470479 [Erwinia amylovora]
MHISTVPATVPVSSRLSPVQVWQQLLTYLLEHHYGLTLNDTPFHDDAAIEEHIDAGITLADAVNFLVERYELVRIDRKGF
TWQEQTPFLAATDILRARRATGLINI

Nucleotide

• Length: 321 bp

>T185027 NZ_CP087880:1326005-1327318 [Pseudocitrobacter corydidari]
ATGCCTAAACTTGTCACATGGATGAACAATCAGCGAGTCGGTGAGTTAACGAAACTGGCCAACGGTGCGCATACGTTTAA
ATATGCGCCGGAATGGTTAGCCAATCGTTATGCCAGGCCATTGTCACTTTCGCTACCGTTGCAGGTGGGGAATATCACCT
CGGATGCGGTTTTTAACTTCTTCGATAACCTGCTGCCTGATAGCCCGATCGTGCGCGACAGGATCGTTAAACGTTATCGC
GCAAAATCAAAGCAACCTTTTGATTTATTGTCAGAAGTCGGTCGAGATAGCGTAGGCGCAGTGACGTTATTACCGGAGGA
TGAAGCGGTGACAAATCCGGTTATGACATGGGAGAAATTAAGTGAGGCAAAGCTTGAAGAGGTGTTGTCGGCTTATAAAT
CAGATATCCCGTTAGGAATGATTAACGCAGAAAATGACTTTCGCATCTCCGTTGCCGGCGCGCAGGAAAAAACCGCGCTG
CTCAAAATGGGCGCTGACTGGTGTATTCCGAAGGGAATAACGCCAACGACGCACATTATCAAATTGCCGATTGGCGAAAT
CAGACAGCCTAATGCGACGCTCGATCTTAGCCAAAGCGTTGATAATGAATATTTTTGTCTGCTGCTGGCGAAACAACTCG
GGTTGAATGTTCCCGGCCCCGAAATCATCAAAGCGGGAAGGGTGCGCGCGTTGGCGGTCGAACGCTTCGACAGACGCTGG
AATACTGAACGGTCAGTTTTACTCCGCTTGCCGCAGGAAGATATGTGCCAGACATTCGGTTTACCGTCATCAGTCAAATA
CGAATCTGACGGAGGCCCGGGTATCGCGCAAATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAGTTTCAGGTGTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAATTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGGCTCACACCATTTTACGACATCATTTCGGCATTTCCGGTTCTTGGCGGTACGGGAATACATAT
CAGCGATTTGAAACTGGCCATGGGGCTTAATGCATCCAAAGGCAGAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGCACTGAAATTCCCGGAAGTACAGATGCGTGAAATCCTGAATGAGTTTGCAGAGCAGATTCCC
GCAGCACTGGATAACGTGACGACTGCATTACCGACAGATTTCCCAGAGAACGTGGCGATGGCAATCCAGACCAATGTGCT
GAGGTTGCATGGGCGGTTAAGCCGGGAGAGATGA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 12088.81 Da
• Isoelectric Point: 6.4689

>AT185027 WP_004155188.1 NZ_CP066794:469799-470122 [Erwinia amylovora]
MSITLPHEWGLQSDITPRFGARLVQEGNRLYYLADRAGLTVSFSPIHLQKLDQAFPLFVEQLENMLRAGELNPHQQHQVT
IQLTSLTCIADTRGSCGYVYISIYPTP

Nucleotide

• Length: 324 bp

>AT185027 NZ_CP087880:1325739-1326005 [Pseudocitrobacter corydidari]
ATGAAGAGCTTCCCGATGATCTACAGCCCAACGCAATTAGCGAATGCAATGAAACTGGTTCGTCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATCGGCATAAAGCAGGCGACCATTTCCAATTTCGAAAATAACCCGGATAACACCACGC
TGACGACTTTTTTTAAGATTTTACAGTCACTTGAGCTCTCAATGACGCTATGCGAAACAAAAGACGCTGCGCCTGAATCT
ACTGACCAACAGGATCTGGAGTGGTAA

Structures

Toxin

• AlphaFold DB: A0A831EPU6

Antitoxin

• AlphaFold DB: A0A831ENV6