Detailed information of TA system TA162503

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 469795..470475
• Replicon: chromosome
• Accession: NZ_CP056034
• Organism: Erwinia amylovora strain TS3128

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: D4HV69
• Locus tag: HU055_RS02170
• Protein ID: WP_004155189.1
• Coordinates: 470155..470475 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: D4HV68
• Locus tag: HU055_RS02165
• Protein ID: WP_004155188.1
• Coordinates: 469795..470118 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HU055_RS02135	464806..465891	-	1086	WP_004155179.1	DNA sulfur modification protein DndB	-
HU055_RS02140	466091..466685	-	595	Protein_418	hypothetical protein	-
HU055_RS02145	466793..466990	-	198	WP_004155182.1	AlpA family phage regulatory protein	-
HU055_RS02150	468200..468442	+	243	WP_004155184.1	hypothetical protein	-
HU055_RS02155	468667..469241	+	575	Protein_421	DUF932 domain-containing protein	-
HU055_RS02160	469312..469782	+	471	WP_004155187.1	DNA repair protein RadC	-
HU055_RS02165	469795..470118	+	324	WP_004155188.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HU055_RS02170	470155..470475	+	321	WP_004155189.1	TA system toxin CbtA family protein	Toxin
HU055_RS02175	470588..471421	+	834	WP_004155190.1	DUF4942 domain-containing protein	-
HU055_RS02180	471518..471766	+	249	WP_004155191.1	ribbon-helix-helix domain-containing protein	-
HU055_RS02185	471770..472045	+	276	WP_004155192.1	type II toxin-antitoxin system RelE/ParE family toxin	-
HU055_RS02190	472464..472664	+	201	Protein_428	transposase	-
HU055_RS02195	472660..472812	+	153	WP_004163933.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_013971 Erwinia amylovora ATCC 49946 Genomic island TA024692 3302629..3325491 0.001 View NZ_NQJO01000001 Erwinia amylovora strain CTBT3-1 tig00000000 Genomic island TA010128, TA294492 3404618..3427747 0.001	inside	Genomic island	-	-	448874..472812	23938
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_013971 Erwinia amylovora ATCC 49946 IS/Tn TA024691, TA024692 3301707..3301931 0 View NZ_NQJO01000001 Erwinia amylovora strain CTBT3-1 tig00000000 IS/Tn TA010128, TA294492 3403975..3404199 0	flank	IS/Tn	-	-	472464..472688	224

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (5-105)

Antitoxin

• Antitoxin CbeA (7-106)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12023.69 Da
• Isoelectric Point: 5.4732

>T162503 WP_004155189.1 NZ_CP056034:470155-470475 [Erwinia amylovora]
MHISTVPATVPVSSRLSPVQVWQQLLTYLLEHHYGLTLNDTPFHDDAAIEEHIDAGITLADAVNFLVERYELVRIDRKGF
TWQEQTPFLAATDILRARRATGLINI

Nucleotide

• Length: 321 bp

>T162503 NZ_CP071821:c74335-73853 [Klebsiella pneumoniae subsp. pneumoniae]
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCTCTCATCAGCGGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACACAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGGACGA
AGCAAGTAGCTGGTTTTTACTCTCTGGCCACCGGTAGCGTTAACCATACGGAAGCTACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTTCACGATGCCGTTCTACGCTGTTATCGCGTAGCTGAGAATATTGGCGTCCGTGCGATAATGGTTCACGCGCTTACTG
AAGAAGCTAAAGGCTTCTATACTCACCATGGATTTACGGCATCGCAAACTCATGAGCGGACTCTGTTCCTTAAACTTCCA
TGA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 12088.81 Da
• Isoelectric Point: 6.4689

>AT162503 WP_004155188.1 NZ_CP056034:469795-470118 [Erwinia amylovora]
MSITLPHEWGLQSDITPRFGARLVQEGNRLYYLADRAGLTVSFSPIHLQKLDQAFPLFVEQLENMLRAGELNPHQQHQVT
IQLTSLTCIADTRGSCGYVYISIYPTP

Nucleotide

• Length: 324 bp

>AT162503 NZ_CP071821:c74589-74323 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATTGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Structures

Toxin

• AlphaFold DB: A0A831EPU6

Antitoxin

• AlphaFold DB: A0A831ENV6