162043

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 469616..470296 Replicon chromosome
Accession NZ_CP055227
Organism Erwinia amylovora strain Ea1189

Toxin (Protein)


Gene name yeeV Uniprot ID D4HV69
Locus tag GTU81_RS02175 Protein ID WP_004155189.1
Coordinates 469976..470296 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID D4HV68
Locus tag GTU81_RS02170 Protein ID WP_004155188.1
Coordinates 469616..469939 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTU81_RS02140 464627..465712 - 1086 WP_004155179.1 DNA sulfur modification protein DndB -
GTU81_RS02145 465912..466506 - 595 Protein_419 hypothetical protein -
GTU81_RS02150 466614..466811 - 198 WP_004155182.1 AlpA family phage regulatory protein -
GTU81_RS02155 468021..468263 + 243 WP_004155184.1 hypothetical protein -
GTU81_RS02160 468488..469062 + 575 Protein_422 DUF932 domain-containing protein -
GTU81_RS02165 469133..469603 + 471 WP_004155187.1 DNA repair protein RadC -
GTU81_RS02170 469616..469939 + 324 WP_004155188.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
GTU81_RS02175 469976..470296 + 321 WP_004155189.1 TA system toxin CbtA family protein Toxin
GTU81_RS02180 470409..471242 + 834 WP_004155190.1 DUF4942 domain-containing protein -
GTU81_RS02185 471339..471587 + 249 WP_004155191.1 ribbon-helix-helix domain-containing protein -
GTU81_RS02190 471591..471866 + 276 WP_004155192.1 type II toxin-antitoxin system RelE/ParE family toxin -
GTU81_RS02195 472285..472485 + 201 Protein_429 transposase -
GTU81_RS02200 472481..472633 + 153 WP_004163933.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 448714..472633 23919
flank IS/Tn - - 472285..472509 224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(5-105)

Antitoxin

Antitoxin CbeA

(7-106)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12023.69 Da        Isoelectric Point: 5.4732

>T162043 WP_004155189.1 NZ_CP055227:469976-470296 [Erwinia amylovora]
MHISTVPATVPVSSRLSPVQVWQQLLTYLLEHHYGLTLNDTPFHDDAAIEEHIDAGITLADAVNFLVERYELVRIDRKGF
TWQEQTPFLAATDILRARRATGLINI

Download         Length: 321 bp

>T162043 NZ_CP071491:1680735-1680902 [Glaesserella parasuis]
ATGATAAAACTTCTCAAAAAGAACGGTTGGGAGCTAGATAGCATAGTCGGTAGCCACCACCACTTTGAGAAGAAAAATCA
AAAGGGAGCAGGCAAAGTGACTGTTCCCCACCCGAGAAAAGACTTAGGCTTTCTCGAAAAGAAAATCAGAAAACAAGCGG
GGCTGTAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12088.81 Da        Isoelectric Point: 6.4689

>AT162043 WP_004155188.1 NZ_CP055227:469616-469939 [Erwinia amylovora]
MSITLPHEWGLQSDITPRFGARLVQEGNRLYYLADRAGLTVSFSPIHLQKLDQAFPLFVEQLENMLRAGELNPHQQHQVT
IQLTSLTCIADTRGSCGYVYISIYPTP

Download         Length: 324 bp

>AT162043 NZ_CP071491:1680941-1681348 [Glaesserella parasuis]
ATGTTATACCCACTCATTTTTGAACAAGTTTCCGACGGCTATGTCGTTGCTGTCCCAGATATTGACGGCTGTTATTCTGC
TGGAGATACCCTAGAAGAAACTTATAGCAACGTAAAACAAGCTATAGCACTTCATCTCGAATCTGTCGTCAAAGATGGGG
GAGAAATTCCAACGCCTACCGCTATCGAAAACCACAAAAACGACCCTGATTTAGACGGTCATAACGTATTTTTCGGTGTG
GTTGATGTCGATTTATCGCACCTAATGGGCAAAGCAGAGAAAATCAACATCACCCTCCCTAGCTATCTCATCAAACGCAT
TGATGATTTTGTTGCGGTTCACAAAGAGTATAAAAACCGTAGCAACTTCTTAGCTAAAATCGCAGCGGATAAAATCTTAA
CCGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A831EPU6

Antitoxin

Source ID Structure
AlphaFold DB A0A831ENV6

References