Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 1620302..1620829 Replicon chromosome
Accession NZ_CP076595
Organism Erwinia amylovora isolate CP20130202

Toxin (Protein)


Gene name relE Uniprot ID D4HV72
Locus tag KQH34_RS07550 Protein ID WP_004155192.1
Coordinates 1620302..1620577 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D4HV71
Locus tag KQH34_RS07555 Protein ID WP_004155191.1
Coordinates 1620581..1620829 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQH34_RS07540 (KQH34_07520) 1616021..1619386 + 3366 WP_004155194.1 ATP-binding protein -
KQH34_RS07545 (KQH34_07530) 1619683..1619883 - 201 Protein_1464 transposase -
KQH34_RS07550 (KQH34_07535) 1620302..1620577 - 276 WP_004155192.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KQH34_RS07555 (KQH34_07540) 1620581..1620829 - 249 WP_004155191.1 ribbon-helix-helix domain-containing protein Antitoxin
KQH34_RS07560 (KQH34_07545) 1620926..1621759 - 834 WP_004155190.1 DUF4942 domain-containing protein -
KQH34_RS07565 (KQH34_07550) 1621872..1622192 - 321 WP_004155189.1 TA system toxin CbtA family protein -
KQH34_RS07570 (KQH34_07555) 1622229..1622552 - 324 WP_004155188.1 type IV toxin-antitoxin system YeeU family antitoxin -
KQH34_RS07575 (KQH34_07560) 1622565..1623035 - 471 WP_004155187.1 DNA repair protein RadC -
KQH34_RS07580 (KQH34_07565) 1623106..1623680 - 575 Protein_1471 DUF932 domain-containing protein -
KQH34_RS07585 (KQH34_07570) 1623905..1624147 - 243 WP_004155184.1 hypothetical protein -
KQH34_RS07590 (KQH34_07575) 1625357..1625554 + 198 WP_004155182.1 AlpA family phage regulatory protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1620302..1643473 23171
flank IS/Tn - - 1619659..1619883 224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 11108.44 Da        Isoelectric Point: 5.5782

>T206016 WP_004155192.1 NZ_CP076595:c1620577-1620302 [Erwinia amylovora]
MEIQWTQKAQDDLERIYRFACQYSRQHADNVLERLLIGTSGLADHPRIGVSQIRYEPREVRKILFDDYDVHYEIQRDTIY
IVDLWHTREDR

Download         Length: 276 bp

>T206016 NZ_CP102066:c71442-71101 [Enterococcus faecalis]
ATGAGTGACGAAAAGAAATATATTCCTAAAAAGGGCGATATTGTATGGATAGATTTCGATCCTTCAGCTGAAAAAGAAAT
ACAGAAAAGACGTCCAGGTCTAGTAGTTTCTAGATATGAGTTTAATAGAAAGACATTGTTTGCAGTAATTTGTCCCATAA
CTTCTACAATTAAAAATATGCCAACTCGTTATACATTACCTGATGAAATGGAAACTCATGGACAAGTCGTTATTTCCCAA
TTAAAATCTTTAGACTTTGCAGAAAGAAAGTTAAGCCAAATAGAATATTTACCATTAAAGGATATGGCTAAAATAGATCA
AATCATTGAATACATTTTTTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9121.53 Da        Isoelectric Point: 8.7560

>AT206016 WP_004155191.1 NZ_CP076595:c1620829-1620581 [Erwinia amylovora]
MRQLAKQTISAQIPAELAAAVENLAIELDRSKSWVIKEALTAMIEERERRHQQILKGLADVDAGRVVSHADVVDFANKLK
KS

Download         Length: 249 bp

>AT206016 NZ_CP102066:c71672-71442 [Enterococcus faecalis]
ATGTTAACCACAAAATCTAGAAAACAAGGAAGTTCTGTAGTATTGACATTACCATCTAATAACGGACAGAAACCAAAAGC
AGACCAAGAATATATAGTAATGTATTCTGATGATGGGACAATTACGTTAGTCCCTAAATTACAAGACCCATTTAGTGGTG
GATCAGAAGGGGAGTACTACGAAAAAGATGAATGGCATGACATTGAACCTGGAGGGAGAGAATTATTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A831EQZ9

Antitoxin

Source ID Structure
AlphaFold DB A0A831A0W7

References