208079

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3507004..3507684 Replicon chromosome
Accession NZ_CP077850
Organism Erwinia amylovora strain CP200242 isolate missinsg

Toxin (Protein)


Gene name yeeV Uniprot ID D4HV69
Locus tag KTR61_RS15845 Protein ID WP_004155189.1
Coordinates 3507004..3507324 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID D4HV68
Locus tag KTR61_RS15850 Protein ID WP_004155188.1
Coordinates 3507361..3507684 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTR61_RS15825 (KTR61_15790) 3504815..3505015 - 201 Protein_3055 transposase -
KTR61_RS15830 (KTR61_15795) 3505434..3505709 - 276 WP_004155192.1 type II toxin-antitoxin system RelE/ParE family toxin -
KTR61_RS15835 (KTR61_15800) 3505713..3505961 - 249 WP_004155191.1 ribbon-helix-helix domain-containing protein -
KTR61_RS15840 (KTR61_15805) 3506058..3506891 - 834 WP_004155190.1 DUF4942 domain-containing protein -
KTR61_RS15845 (KTR61_15810) 3507004..3507324 - 321 WP_004155189.1 TA system toxin CbtA family protein Toxin
KTR61_RS15850 (KTR61_15815) 3507361..3507684 - 324 WP_004155188.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KTR61_RS15855 (KTR61_15820) 3507697..3508167 - 471 WP_004155187.1 DNA repair protein RadC -
KTR61_RS15860 (KTR61_15825) 3508238..3508812 - 575 Protein_3062 DUF932 domain-containing protein -
KTR61_RS15865 (KTR61_15830) 3509037..3509279 - 243 WP_004155184.1 hypothetical protein -
KTR61_RS15870 (KTR61_15835) 3510489..3510686 + 198 WP_004155182.1 AlpA family phage regulatory protein -
KTR61_RS15875 3510794..3511144 + 351 WP_004155181.1 hypothetical protein -
KTR61_RS15880 (KTR61_15845) 3511588..3512673 + 1086 WP_004155179.1 DNA sulfur modification protein DndB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3505434..3528605 23171
flank IS/Tn - - 3504791..3505015 224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(5-105)

Antitoxin

Antitoxin CbeA

(7-106)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12023.69 Da        Isoelectric Point: 5.4732

>T208079 WP_004155189.1 NZ_CP077850:c3507324-3507004 [Erwinia amylovora]
MHISTVPATVPVSSRLSPVQVWQQLLTYLLEHHYGLTLNDTPFHDDAAIEEHIDAGITLADAVNFLVERYELVRIDRKGF
TWQEQTPFLAATDILRARRATGLINI

Download         Length: 321 bp

>T208079 NZ_CP103562:c4498986-4498636 [Escherichia coli O25b:H4-ST131]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12088.81 Da        Isoelectric Point: 6.4689

>AT208079 WP_004155188.1 NZ_CP077850:c3507684-3507361 [Erwinia amylovora]
MSITLPHEWGLQSDITPRFGARLVQEGNRLYYLADRAGLTVSFSPIHLQKLDQAFPLFVEQLENMLRAGELNPHQQHQVT
IQLTSLTCIADTRGSCGYVYISIYPTP

Download         Length: 324 bp

>AT208079 NZ_CP103562:c4499231-4498980 [Escherichia coli O25b:H4-ST131]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A831EPU6

Antitoxin

Source ID Structure
AlphaFold DB A0A831ENV6

References