Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 466700..467380 Replicon chromosome
Accession NC_013961
Organism Erwinia amylovora CFBP1430

Toxin (Protein)


Gene name yeeV Uniprot ID D4HV69
Locus tag EAMY_RS19305 Protein ID WP_004155189.1
Coordinates 467060..467380 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID D4HV68
Locus tag EAMY_RS19300 Protein ID WP_004155188.1
Coordinates 466700..467023 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EAMY_RS19270 461711..462796 - 1086 WP_004155179.1 DNA sulfur modification protein DndB -
EAMY_RS36285 462996..463590 - 595 Protein_371 hypothetical protein -
EAMY_RS19280 463698..463895 - 198 WP_004155182.1 AlpA family phage regulatory protein -
EAMY_RS34675 465105..465347 + 243 WP_004155184.1 hypothetical protein -
EAMY_RS34680 465572..466146 + 575 Protein_374 DUF932 domain-containing protein -
EAMY_RS19295 466217..466687 + 471 WP_004155187.1 DNA repair protein RadC -
EAMY_RS19300 466700..467023 + 324 WP_004155188.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EAMY_RS19305 467060..467380 + 321 WP_004155189.1 TA system toxin CbtA family protein Toxin
EAMY_RS19310 467493..468326 + 834 WP_004155190.1 DUF4942 domain-containing protein -
EAMY_RS19315 468423..468671 + 249 WP_004155191.1 ribbon-helix-helix domain-containing protein -
EAMY_RS19320 468675..468950 + 276 WP_004155192.1 type II toxin-antitoxin system RelE/ParE family toxin -
EAMY_RS19325 469369..469569 + 201 Protein_381 transposase -
EAMY_RS36140 469565..469717 + 153 WP_004163933.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 445798..469717 23919
flank IS/Tn - - 469369..469593 224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(5-105)

Antitoxin

Antitoxin CbeA

(7-106)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12023.69 Da        Isoelectric Point: 5.4732

>T24673 WP_004155189.1 NC_013961:467060-467380 [Erwinia amylovora CFBP1430]
MHISTVPATVPVSSRLSPVQVWQQLLTYLLEHHYGLTLNDTPFHDDAAIEEHIDAGITLADAVNFLVERYELVRIDRKGF
TWQEQTPFLAATDILRARRATGLINI

Download         Length: 321 bp

>T24673 NC_013961:467060-467380 [Erwinia amylovora CFBP1430]
ATGCACATTTCAACTGTACCGGCCACGGTGCCGGTTTCGTCACGCCTGTCTCCCGTGCAGGTGTGGCAGCAACTTTTAAC
GTATCTGCTGGAGCATCATTACGGCTTGACACTAAATGACACGCCATTCCATGACGACGCGGCCATTGAGGAGCATATCG
ACGCAGGAATCACGCTCGCCGATGCTGTTAATTTTCTGGTGGAACGTTATGAACTGGTACGTATCGACCGCAAAGGATTT
ACATGGCAGGAGCAGACGCCATTCCTGGCCGCCACCGATATTCTCAGAGCAAGGCGAGCTACCGGATTAATAAATATTTA
A

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12088.81 Da        Isoelectric Point: 6.4689

>AT24673 WP_004155188.1 NC_013961:466700-467023 [Erwinia amylovora CFBP1430]
MSITLPHEWGLQSDITPRFGARLVQEGNRLYYLADRAGLTVSFSPIHLQKLDQAFPLFVEQLENMLRAGELNPHQQHQVT
IQLTSLTCIADTRGSCGYVYISIYPTP

Download         Length: 324 bp

>AT24673 NC_013961:466700-467023 [Erwinia amylovora CFBP1430]
ATGTCAATCACACTACCTCATGAATGGGGTCTACAAAGCGATATCACCCCACGATTTGGCGCGAGATTAGTTCAGGAAGG
CAATCGGCTGTATTACCTGGCTGACAGGGCTGGATTAACGGTGAGCTTTAGCCCGATACACCTGCAGAAACTGGATCAGG
CTTTCCCGCTGTTTGTAGAACAACTGGAAAATATGCTGCGTGCTGGCGAACTAAATCCACATCAGCAACATCAGGTGACC
ATTCAACTTACGAGTTTAACCTGTATAGCTGATACCCGTGGTAGCTGCGGTTACGTTTACATTTCTATTTATCCAACCCC
ATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A831EPU6

Antitoxin

Source ID Structure
AlphaFold DB A0A831ENV6

References