Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 3505434..3505961 Replicon chromosome
Accession NZ_CP077850
Organism Erwinia amylovora strain CP200242 isolate missinsg

Toxin (Protein)


Gene name relE Uniprot ID D4HV72
Locus tag KTR61_RS15830 Protein ID WP_004155192.1
Coordinates 3505434..3505709 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D4HV71
Locus tag KTR61_RS15835 Protein ID WP_004155191.1
Coordinates 3505713..3505961 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTR61_RS15820 (KTR61_15780) 3501153..3504518 + 3366 WP_004155194.1 ATP-binding protein -
KTR61_RS15825 (KTR61_15790) 3504815..3505015 - 201 Protein_3055 transposase -
KTR61_RS15830 (KTR61_15795) 3505434..3505709 - 276 WP_004155192.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KTR61_RS15835 (KTR61_15800) 3505713..3505961 - 249 WP_004155191.1 ribbon-helix-helix domain-containing protein Antitoxin
KTR61_RS15840 (KTR61_15805) 3506058..3506891 - 834 WP_004155190.1 DUF4942 domain-containing protein -
KTR61_RS15845 (KTR61_15810) 3507004..3507324 - 321 WP_004155189.1 TA system toxin CbtA family protein -
KTR61_RS15850 (KTR61_15815) 3507361..3507684 - 324 WP_004155188.1 type IV toxin-antitoxin system YeeU family antitoxin -
KTR61_RS15855 (KTR61_15820) 3507697..3508167 - 471 WP_004155187.1 DNA repair protein RadC -
KTR61_RS15860 (KTR61_15825) 3508238..3508812 - 575 Protein_3062 DUF932 domain-containing protein -
KTR61_RS15865 (KTR61_15830) 3509037..3509279 - 243 WP_004155184.1 hypothetical protein -
KTR61_RS15870 (KTR61_15835) 3510489..3510686 + 198 WP_004155182.1 AlpA family phage regulatory protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3505434..3528605 23171
flank IS/Tn - - 3504791..3505015 224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 11108.44 Da        Isoelectric Point: 5.5782

>T208078 WP_004155192.1 NZ_CP077850:c3505709-3505434 [Erwinia amylovora]
MEIQWTQKAQDDLERIYRFACQYSRQHADNVLERLLIGTSGLADHPRIGVSQIRYEPREVRKILFDDYDVHYEIQRDTIY
IVDLWHTREDR

Download         Length: 276 bp

>T208078 NZ_CP103562:4396165-4396542 [Escherichia coli O25b:H4-ST131]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCAGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9121.53 Da        Isoelectric Point: 8.7560

>AT208078 WP_004155191.1 NZ_CP077850:c3505961-3505713 [Erwinia amylovora]
MRQLAKQTISAQIPAELAAAVENLAIELDRSKSWVIKEALTAMIEERERRHQQILKGLADVDAGRVVSHADVVDFANKLK
KS

Download         Length: 249 bp

>AT208078 NZ_CP103562:4395707-4396075 [Escherichia coli O25b:H4-ST131]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A831EQZ9

Antitoxin

Source ID Structure
AlphaFold DB A0A831A0W7

References