181839

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 471942..472469 Replicon chromosome
Accession NZ_CP064855
Organism Erwinia amylovora strain Ea1/79Sm

Toxin (Protein)


Gene name relE Uniprot ID D4HV72
Locus tag IYV53_RS02185 Protein ID WP_004155192.1
Coordinates 472194..472469 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D4HV71
Locus tag IYV53_RS02180 Protein ID WP_004155191.1
Coordinates 471942..472190 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IYV53_RS02145 467217..467414 - 198 WP_004155182.1 AlpA family phage regulatory protein -
IYV53_RS02150 468624..468866 + 243 WP_004155184.1 hypothetical protein -
IYV53_RS02155 469091..469665 + 575 Protein_421 DUF932 domain-containing protein -
IYV53_RS02160 469736..470206 + 471 WP_004155187.1 DNA repair protein RadC -
IYV53_RS02165 470219..470542 + 324 WP_004155188.1 type IV toxin-antitoxin system YeeU family antitoxin -
IYV53_RS02170 470579..470899 + 321 WP_004155189.1 TA system toxin CbtA family protein -
IYV53_RS02175 471012..471845 + 834 WP_004155190.1 DUF4942 domain-containing protein -
IYV53_RS02180 471942..472190 + 249 WP_004155191.1 ribbon-helix-helix domain-containing protein Antitoxin
IYV53_RS02185 472194..472469 + 276 WP_004155192.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IYV53_RS02190 472888..473088 + 201 Protein_428 transposase -
IYV53_RS02195 473084..473236 + 153 WP_004163933.1 hypothetical protein -
IYV53_RS02200 473385..476750 - 3366 WP_004155194.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 449316..473236 23920
flank IS/Tn - - 472888..473112 224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 11108.44 Da        Isoelectric Point: 5.5782

>T181839 WP_004155192.1 NZ_CP064855:472194-472469 [Erwinia amylovora]
MEIQWTQKAQDDLERIYRFACQYSRQHADNVLERLLIGTSGLADHPRIGVSQIRYEPREVRKILFDDYDVHYEIQRDTIY
IVDLWHTREDR

Download         Length: 276 bp

>T181839 NZ_CP086183:c4779418-4779266 [Xanthomonas oryzae]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGGCCGGCGTGATGACGGGCTGCAACACCGTGGCTGGCGC
TGGCAAGGACTTGCAGGGCGCGGGTGGGAAGGTCGAGAAAACGGCCGAAAAATGCAGCGATGGTAAGTGCTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9121.53 Da        Isoelectric Point: 8.7560

>AT181839 WP_004155191.1 NZ_CP064855:471942-472190 [Erwinia amylovora]
MRQLAKQTISAQIPAELAAAVENLAIELDRSKSWVIKEALTAMIEERERRHQQILKGLADVDAGRVVSHADVVDFANKLK
KS

Download         Length: 249 bp

>AT181839 NZ_CP086183:c4779202-4779068 [Xanthomonas oryzae]
ATGAAGCGTGCAATTGTGCTGCTCGTGCTGTCCATGTTGTCGGTCGGTCTGCTGTCGGGCTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGAAGGGCGCCGGCGAGAAGGTGGAAGACGCAGCGCGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A831EQZ9

Antitoxin

Source ID Structure
AlphaFold DB A0A831A0W7

References