Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 246178..246705 Replicon chromosome
Accession NZ_CP076590
Organism Erwinia amylovora isolate CP200930

Toxin (Protein)


Gene name relE Uniprot ID D4HV72
Locus tag KQH39_RS01240 Protein ID WP_004155192.1
Coordinates 246430..246705 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D4HV71
Locus tag KQH39_RS01235 Protein ID WP_004155191.1
Coordinates 246178..246426 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQH39_RS01200 (KQH39_01210) 241453..241650 - 198 WP_004155182.1 AlpA family phage regulatory protein -
KQH39_RS01205 (KQH39_01215) 242860..243102 + 243 WP_004155184.1 hypothetical protein -
KQH39_RS01210 (KQH39_01220) 243327..243901 + 575 Protein_232 DUF932 domain-containing protein -
KQH39_RS01215 (KQH39_01225) 243972..244442 + 471 WP_004155187.1 DNA repair protein RadC -
KQH39_RS01220 (KQH39_01230) 244455..244778 + 324 WP_004155188.1 type IV toxin-antitoxin system YeeU family antitoxin -
KQH39_RS01225 (KQH39_01235) 244815..245135 + 321 WP_004155189.1 TA system toxin CbtA family protein -
KQH39_RS01230 (KQH39_01240) 245248..246081 + 834 WP_004155190.1 DUF4942 domain-containing protein -
KQH39_RS01235 (KQH39_01245) 246178..246426 + 249 WP_004155191.1 ribbon-helix-helix domain-containing protein Antitoxin
KQH39_RS01240 (KQH39_01250) 246430..246705 + 276 WP_004155192.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KQH39_RS01245 (KQH39_01255) 247124..247324 + 201 Protein_239 transposase -
KQH39_RS01250 (KQH39_01265) 247621..250986 - 3366 WP_004155194.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 223534..247472 23938
flank IS/Tn - - 247124..247348 224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 11108.44 Da        Isoelectric Point: 5.5782

>T205973 WP_004155192.1 NZ_CP076590:246430-246705 [Erwinia amylovora]
MEIQWTQKAQDDLERIYRFACQYSRQHADNVLERLLIGTSGLADHPRIGVSQIRYEPREVRKILFDDYDVHYEIQRDTIY
IVDLWHTREDR

Download         Length: 276 bp

>T205973 NZ_CP101984:c1330230-1330039 [Streptococcus mutans]
TTGCCATTAACAGGGAAAGAATTAGCTAAATTAGCGATAAACAATGGATGGGAAGAAGTTCGGGTGAGAGGAAGTCATCA
TCATTTCAAGAAAGATGGAGTATCTTATATTGTGACGATTCCTATTCATGGAAATAAAGTGCTTAAAATTGGTCTTGAAA
AGAAACTCTTAAGGGATTTAAATTTATTATGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9121.53 Da        Isoelectric Point: 8.7560

>AT205973 WP_004155191.1 NZ_CP076590:246178-246426 [Erwinia amylovora]
MRQLAKQTISAQIPAELAAAVENLAIELDRSKSWVIKEALTAMIEERERRHQQILKGLADVDAGRVVSHADVVDFANKLK
KS

Download         Length: 249 bp

>AT205973 NZ_CP101984:c1330021-1329644 [Streptococcus mutans]
ATGTTAAAATCATATCCTGTAATTTTTCATAAGGAAGAGGAAGGGTATTGGGTTGAATTTCCTGAATTTGGCGGTGGTAC
GCAAGGGGAAGATTTGGAAGAAGCCATGAAGAACGCTCGTCAGATGTTAGAAAGTGTGTTGGCATCTTATCTTGATGAAG
GGTTGGTTCTACCCATTTCAAGCGATATTCAGAAAATATCTGTTGAAGATGGTTTTGCGACCATGATTCAAGCTGATCCT
AGTCCTTATCTCAAAAATAACAAAGCTATTCGGAAAAATGTTACCGTGCCTGAGTGGTTGATACGATTAGCAGACCGTGA
CCGAGTAAATTATTCTGAAGTATTAACAAAGGCTTTGGAAAAGAAACTACAATTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A831EQZ9

Antitoxin

Source ID Structure
AlphaFold DB A0A831A0W7

References