Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 471339..471866 Replicon chromosome
Accession NZ_CP055227
Organism Erwinia amylovora strain Ea1189

Toxin (Protein)


Gene name relE Uniprot ID D4HV72
Locus tag GTU81_RS02190 Protein ID WP_004155192.1
Coordinates 471591..471866 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D4HV71
Locus tag GTU81_RS02185 Protein ID WP_004155191.1
Coordinates 471339..471587 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTU81_RS02150 466614..466811 - 198 WP_004155182.1 AlpA family phage regulatory protein -
GTU81_RS02155 468021..468263 + 243 WP_004155184.1 hypothetical protein -
GTU81_RS02160 468488..469062 + 575 Protein_422 DUF932 domain-containing protein -
GTU81_RS02165 469133..469603 + 471 WP_004155187.1 DNA repair protein RadC -
GTU81_RS02170 469616..469939 + 324 WP_004155188.1 type IV toxin-antitoxin system YeeU family antitoxin -
GTU81_RS02175 469976..470296 + 321 WP_004155189.1 TA system toxin CbtA family protein -
GTU81_RS02180 470409..471242 + 834 WP_004155190.1 DUF4942 domain-containing protein -
GTU81_RS02185 471339..471587 + 249 WP_004155191.1 ribbon-helix-helix domain-containing protein Antitoxin
GTU81_RS02190 471591..471866 + 276 WP_004155192.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GTU81_RS02195 472285..472485 + 201 Protein_429 transposase -
GTU81_RS02200 472481..472633 + 153 WP_004163933.1 hypothetical protein -
GTU81_RS02205 472782..476147 - 3366 WP_004155194.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 448714..472633 23919
flank IS/Tn - - 472285..472509 224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 11108.44 Da        Isoelectric Point: 5.5782

>T162044 WP_004155192.1 NZ_CP055227:471591-471866 [Erwinia amylovora]
MEIQWTQKAQDDLERIYRFACQYSRQHADNVLERLLIGTSGLADHPRIGVSQIRYEPREVRKILFDDYDVHYEIQRDTIY
IVDLWHTREDR

Download         Length: 276 bp

>T162044 NZ_CP071502:372917-374251 [Shewanella sp. FJAT-52962]
ATGGCAGTCTTGGATGTGTATATGAATGGCTATCTGATTGGCGAATTCACCAAAACATCGACCGGTGCCCACTATTTTAG
CTACCACGAAGACTGGTTGGCTGTGGCGGGGGCCCGCCCCATCTCTTTATCGATGCCGTTGCGCCGTCAAGCTTATAAAG
GGGATGAGGTATACAACTTCTTTGATAACCTGCTCCCTGATAACCCTGAGGTGCGTAACCGCATTGTTGCCCGTCATCAA
GCTGTATCCTCACAGCCTTTTGATTTGCTGGCCAAGATTGGCCAAGACAGTGTGGGGGCATTGCAGTTGGTGCCCCATGG
TGAAGTGCCTGTGAACGTCAAGCAAATCGAATCTAAAGCACTTTCTGAAGCCGATTTGGAAAAGGTGTTGAAGGGATACC
TATCGGGCATTCCACTCGGCATGCTGCGTGAGCAGGATGAGTTTAGGATCTCGATCGCCGGTGCACAGGAAAAAACGGCA
CTGCTGAATCTCAATGGGCAGTGGCGGCTGCCCATACATGCAACGCCTACAACCCATATCATCAAGTTGCCAATTGGCAC
CATAAAAGGCCATTCGTTCAATATCGATATGTCTGACAGTGTTGAGAACGAGTTCCTCTGCATGAAGATTGCTGAAGCGT
TTGGCTTAACTGCCGCGCAATGCCACATCATGAAAGTGGGCGACATTAAGGCGCTGGCAGTTGAACGATTCGATCGCCGC
TTTGCTGCAGATGGCAGTTGGATCATGCGTCTTCCCCAAGAGGATTTTTGTCAGGTACTGAATGTCCCACCAGCCAATAA
ATATGAGAGTGACGGCGGACCGGGAATTCAGGCCATCATGGATCAGCTATTGGGTTCAACGAATCCTGAACGTGACCGGC
ACGACTTTATGAAAGCCCAGGTGTTGTTTTGGCTGTTGGGTGCAATTGATGGGCATGCCAAGAATTTCTCTATTTTCATT
GATGCTGGTGGCAGTTATCGTTTGGCGCCCCTTTACGACATACTGTCAATTTACCCCGCCCTTGGGGGGCAAGGACCCAA
CATACGCGATGTGAAACTCGCGATGGCTTTAAAAGCGAGCAAAGGTAAAAAGGCGCAGCTGGATGCCATCTTTCCCAGGC
ACTTTATTCAAACAGCCAAAGCTGTGGGTTTTGATCCCGATACCATGGCCGGGATCATGATGGAAATCGCTGATATGCTG
GAACCCGTTATTGCCAAAGTGCGGGCTGAGCTTCCCACAGATTTCCCTGAACATATACGCGAGTCAATACTGAATGGGCT
CACTGAACGGGCAAAGCGCCTGACCGCAGAAAATATCTGGCAGGCTAGCCGTTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9121.53 Da        Isoelectric Point: 8.7560

>AT162044 WP_004155191.1 NZ_CP055227:471339-471587 [Erwinia amylovora]
MRQLAKQTISAQIPAELAAAVENLAIELDRSKSWVIKEALTAMIEERERRHQQILKGLADVDAGRVVSHADVVDFANKLK
KS

Download         Length: 249 bp

>AT162044 NZ_CP071502:372648-372917 [Shewanella sp. FJAT-52962]
ATGAAGGTGACGACCTCAAAGCAGTTAAGCAATTATCTAAAAGATGCCCGTTTAGCGATGAAACTTTCACAGAGTAAAGT
CGCAAACAAAGTGGGCATCCGCCAGGATACAGTGTCGAGTTTTGAGCAAAATCCAGACTCAACCAAACTAGAGACCCTTT
TCAAGCTGCTGTCATCACTCAACCTTGAGCTTGAGGTTCGGCCAAGAGCATCGGATGCAGACTCTGCTGGCACAACTCAT
GATACCCAGAATTGGAAAGAGGAATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A831EQZ9

Antitoxin

Source ID Structure
AlphaFold DB A0A831A0W7

References