22270

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2117100..2117523 Replicon chromosome
Accession NC_009641
Organism Staphylococcus aureus subsp. aureus str. Newman

Toxin (Protein)


Gene name higB Uniprot ID A0A5S9I4Y6
Locus tag NWMN_RS10975 Protein ID WP_001065091.1
Coordinates 2117272..2117523 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0E0VQM8
Locus tag NWMN_RS10970 Protein ID WP_000028422.1
Coordinates 2117100..2117282 (-) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWMN_RS10925 (NWMN_1899) 2112486..2114147 - 1662 WP_000625088.1 terminase large subunit -
NWMN_RS10930 (NWMN_1900) 2114144..2114488 - 345 WP_000402904.1 hypothetical protein -
NWMN_RS10935 (NWMN_1901) 2114618..2114917 - 300 WP_000988336.1 HNH endonuclease -
NWMN_RS10940 (NWMN_1902) 2115149..2115565 - 417 WP_000590122.1 hypothetical protein -
NWMN_RS10945 2115593..2115793 - 201 WP_000265043.1 DUF1514 family protein -
NWMN_RS10950 2115793..2115942 - 150 WP_000595265.1 transcriptional activator RinB -
NWMN_RS10955 (NWMN_1903) 2115939..2116325 - 387 WP_000592210.1 hypothetical protein -
NWMN_RS10960 2116322..2116528 - 207 WP_000195803.1 DUF1381 domain-containing protein -
NWMN_RS10965 (NWMN_1904) 2116565..2117107 - 543 WP_000185659.1 dUTP pyrophosphatase -
NWMN_RS10970 2117100..2117282 - 183 WP_000028422.1 hypothetical protein Antitoxin
NWMN_RS10975 (NWMN_1905) 2117272..2117523 - 252 WP_001065091.1 DUF1024 family protein Toxin
NWMN_RS15895 (NWMN_2622) 2117516..2117683 - 168 WP_001624242.1 hypothetical protein -
NWMN_RS10980 (NWMN_2623) 2117695..2117937 - 243 WP_000131366.1 hypothetical protein -
NWMN_RS10985 (NWMN_1906) 2117941..2118309 - 369 WP_000101274.1 hypothetical protein -
NWMN_RS10990 (NWMN_1907) 2118322..2118726 - 405 WP_000401960.1 RusA family crossover junction endodeoxyribonuclease -
NWMN_RS10995 2118735..2118953 - 219 WP_000338530.1 hypothetical protein -
NWMN_RS11000 (NWMN_1908) 2118960..2119844 - 885 WP_000148316.1 DnaD domain protein -
NWMN_RS11005 (NWMN_1909) 2119874..2120344 - 471 WP_000934764.1 single-stranded DNA-binding protein -
NWMN_RS11010 (NWMN_1910) 2120345..2120962 - 618 WP_071621397.1 MBL fold metallo-hydrolase -
NWMN_RS11015 (NWMN_1911) 2121043..2121963 - 921 WP_000138472.1 recombinase RecT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / chp / sak / sea / hlb / groEL 2089433..2146383 56950


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9349.22 Da        Isoelectric Point: 3.9473

>T22270 WP_001065091.1 NC_009641:c2117523-2117272 [Staphylococcus aureus subsp. aureus str. Newman]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEH

Download         Length: 252 bp

>T22270 NC_009641:c2117523-2117272 [Staphylococcus aureus subsp. aureus str. Newman]
ATGAATAATCGCGAACAAATTGAACAATCAGTTATAAGTGCTAGTGCGTATAACGGTAATGACACAGAGGGATTACTAAA
AGAGATTGAGGACGTTTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAACATTCAG
TTAAAGAAGGTGTTGAACTTGATGAAGCAGTAGGGATTATGGCAGGTCAAGTTGTCTATAAATATGAGGAGGAACAGGAA
AATGAGCATTAG

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6741.63 Da        Isoelectric Point: 4.2658

>AT22270 WP_000028422.1 NC_009641:c2117282-2117100 [Staphylococcus aureus subsp. aureus str. Newman]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEEQEND

Download         Length: 183 bp

>AT22270 NC_009641:c2117282-2117100 [Staphylococcus aureus subsp. aureus str. Newman]
ATGAGCATTAGTGTAGGAGACAAGGTTTTTAATCCAGAAACAAATTCAACTTTAGAAATTGTACAACTTGTTGGCGATAT
TAGAGACACGCATTACAAGTTATCTGACGGATCTATTATTAGTCTTATAGACTTTGTTGTTAAACCAATTCATTTAATCA
AGGAGGAGCAGGAAAATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5S9I4Y6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VQM8

References