208216

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 2661843..2662181 Replicon chromosome
Accession NZ_CP077859
Organism Staphylococcus aureus strain AC5

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag KU537_RS13055 Protein ID WP_011447039.1
Coordinates 2661843..2662019 (+) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 2662007..2662181 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU537_RS13035 2659624..2659776 + 153 WP_001153681.1 hypothetical protein -
KU537_RS13040 2659823..2660110 + 288 WP_001040259.1 hypothetical protein -
KU537_RS13045 2660166..2660540 + 375 WP_000340977.1 hypothetical protein -
KU537_RS13050 2660961..2661734 + 774 WP_000750406.1 staphylococcal enterotoxin type A -
KU537_RS13055 2661843..2662019 + 177 WP_011447039.1 type I toxin-antitoxin system toxin PepG1 Toxin
- 2662007..2662181 - 175 - - Antitoxin
KU537_RS13065 2662231..2662485 + 255 WP_000611512.1 phage holin -
KU537_RS13070 2662497..2663252 + 756 WP_000861038.1 CHAP domain-containing protein -
KU537_RS13075 2663443..2663934 + 492 WP_000919350.1 staphylokinase -
KU537_RS13080 2664584..2664919 + 336 Protein_2567 SH3 domain-containing protein -
KU537_RS13085 2665014..2665463 - 450 WP_000727649.1 chemotaxis-inhibiting protein CHIPS -
KU537_RS13090 2666149..2666499 + 351 WP_000702263.1 complement inhibitor SCIN-A -
KU537_RS13095 2666552..2666812 - 261 WP_001791826.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - groEL / hlb / sea / sak / chp / scn / hlb / map 2614667..2671510 56843


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T208216 WP_011447039.1 NZ_CP077859:2661843-2662019 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T208216 NZ_CP103592:c4352861-4352484 [Escherichia coli O25b:H4-ST131]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCAGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 175 bp

>AT208216 NZ_CP077859:c2662181-2662007 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References