Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 2678722..2679060 Replicon chromosome
Accession NZ_CP077857
Organism Staphylococcus aureus strain L4

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag KU533_RS13255 Protein ID WP_011447039.1
Coordinates 2678722..2678898 (+) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 2678886..2679060 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU533_RS13235 2676503..2676655 + 153 WP_001153681.1 hypothetical protein -
KU533_RS13240 2676702..2676989 + 288 WP_001040259.1 hypothetical protein -
KU533_RS13245 2677045..2677419 + 375 WP_000340977.1 hypothetical protein -
KU533_RS13250 2677840..2678613 + 774 WP_000750406.1 staphylococcal enterotoxin type A -
KU533_RS13255 2678722..2678898 + 177 WP_011447039.1 type I toxin-antitoxin system toxin PepG1 Toxin
- 2678886..2679060 - 175 - - Antitoxin
KU533_RS13265 2679110..2679364 + 255 WP_000611512.1 phage holin -
KU533_RS13270 2679376..2680131 + 756 WP_000861038.1 CHAP domain-containing protein -
KU533_RS13275 2680322..2680813 + 492 WP_000919350.1 staphylokinase -
KU533_RS13280 2681463..2681798 + 336 Protein_2576 SH3 domain-containing protein -
KU533_RS13285 2681893..2682342 - 450 WP_000727649.1 chemotaxis-inhibiting protein CHIPS -
KU533_RS13290 2683028..2683378 + 351 WP_000702263.1 complement inhibitor SCIN-A -
KU533_RS13295 2683431..2683691 - 261 WP_001791826.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - hlb / sea / sak / chp / scn / hlb / map 2635813..2688389 52576


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T208181 WP_011447039.1 NZ_CP077857:2678722-2678898 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T208181 NZ_CP103589:1959491-1959745 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 175 bp

>AT208181 NZ_CP077857:c2679060-2678886 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References