Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1765480..1765903 Replicon chromosome
Accession NZ_CP041010
Organism Staphylococcus aureus strain FDAARGOS_766

Toxin (Protein)


Gene name higB Uniprot ID A0A5S9I4Y6
Locus tag FIU19_RS09485 Protein ID WP_001065091.1
Coordinates 1765652..1765903 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0E0VQM8
Locus tag FIU19_RS09480 Protein ID WP_000028422.1
Coordinates 1765480..1765662 (-) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FIU19_RS09435 1760866..1762527 - 1662 WP_000625088.1 terminase large subunit -
FIU19_RS09440 1762524..1762868 - 345 WP_000402904.1 hypothetical protein -
FIU19_RS09445 1762998..1763297 - 300 WP_000988336.1 HNH endonuclease -
FIU19_RS09450 1763529..1763945 - 417 WP_000590122.1 hypothetical protein -
FIU19_RS09455 1763973..1764173 - 201 WP_000265043.1 DUF1514 family protein -
FIU19_RS09460 1764173..1764322 - 150 WP_000595265.1 transcriptional activator RinB -
FIU19_RS09465 1764319..1764705 - 387 WP_000592207.1 hypothetical protein -
FIU19_RS09470 1764702..1764908 - 207 WP_000195803.1 DUF1381 domain-containing protein -
FIU19_RS09475 1764945..1765487 - 543 WP_000185659.1 dUTP pyrophosphatase -
FIU19_RS09480 1765480..1765662 - 183 WP_000028422.1 hypothetical protein Antitoxin
FIU19_RS09485 1765652..1765903 - 252 WP_001065091.1 DUF1024 family protein Toxin
FIU19_RS15630 1765896..1766060 - 165 WP_000990744.1 hypothetical protein -
FIU19_RS09490 1766075..1766317 - 243 WP_000131366.1 hypothetical protein -
FIU19_RS09495 1766321..1766689 - 369 WP_000101274.1 hypothetical protein -
FIU19_RS09500 1766702..1767011 - 310 Protein_1737 RusA family crossover junction endodeoxyribonuclease -
FIU19_RS09505 1767020..1767238 - 219 WP_000338531.1 hypothetical protein -
FIU19_RS09510 1767245..1768118 - 874 Protein_1739 DnaD domain protein -
FIU19_RS09515 1768148..1768618 - 471 WP_000934764.1 single-stranded DNA-binding protein -
FIU19_RS09520 1768619..1769236 - 618 WP_071621397.1 MBL fold metallo-hydrolase -
FIU19_RS09525 1769317..1770237 - 921 WP_000138472.1 recombinase RecT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / chp / sak / sea / hlb 1736480..1786579 50099


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9349.22 Da        Isoelectric Point: 3.9473

>T127398 WP_001065091.1 NZ_CP041010:c1765903-1765652 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEH

Download         Length: 252 bp

>T127398 NZ_CP041010:c1765903-1765652 [Staphylococcus aureus]
ATGAATAATCGCGAACAAATTGAACAATCAGTTATAAGTGCTAGTGCGTATAACGGTAATGACACAGAGGGATTACTAAA
AGAGATTGAGGACGTTTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAACATTCAG
TTAAAGAAGGTGTTGAACTTGATGAAGCAGTAGGGATTATGGCAGGTCAAGTTGTCTATAAATATGAGGAGGAACAGGAA
AATGAGCATTAG

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6741.63 Da        Isoelectric Point: 4.2658

>AT127398 WP_000028422.1 NZ_CP041010:c1765662-1765480 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEEQEND

Download         Length: 183 bp

>AT127398 NZ_CP041010:c1765662-1765480 [Staphylococcus aureus]
ATGAGCATTAGTGTAGGAGACAAGGTTTTTAATCCAGAAACAAATTCAACTTTAGAAATTGTACAACTTGTTGGCGATAT
TAGAGACACGCATTACAAGTTATCTGACGGATCTATTATTAGTCTTATAGACTTTGTTGTTAAACCAATTCATTTAATCA
AGGAGGAGCAGGAAAATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5S9I4Y6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VQM8

References