Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF3/-
Location 2093789..2094088 Replicon chromosome
Accession NZ_CP023390
Organism Staphylococcus aureus subsp. aureus str. Newman strain NYU_Newman

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag CNH35_RS11085 Protein ID WP_011447039.1
Coordinates 2093912..2094088 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF3
Locus tag -
Coordinates 2093789..2093844 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CNH35_RS11040 2089120..2089380 + 261 WP_001791826.1 hypothetical protein -
CNH35_RS11045 2089433..2089783 - 351 WP_000702263.1 complement inhibitor SCIN-A -
CNH35_RS11050 2090468..2090917 + 450 WP_000727649.1 chemotaxis-inhibiting protein CHIPS -
CNH35_RS11055 2091012..2091347 - 336 Protein_2047 SH3 domain-containing protein -
CNH35_RS11065 2091997..2092488 - 492 WP_000919350.1 staphylokinase -
CNH35_RS11070 2092679..2093434 - 756 WP_000861038.1 CHAP domain-containing protein -
CNH35_RS11075 2093446..2093700 - 255 WP_000611512.1 phage holin -
CNH35_RS11080 2093752..2093859 + 108 WP_001791821.1 hypothetical protein -
- 2093781..2093920 + 140 NuclAT_0 - -
- 2093781..2093920 + 140 NuclAT_0 - -
- 2093781..2093920 + 140 NuclAT_0 - -
- 2093781..2093920 + 140 NuclAT_0 - -
- 2093789..2093844 + 56 - - Antitoxin
CNH35_RS11085 2093912..2094088 - 177 WP_011447039.1 putative holin-like toxin Toxin
CNH35_RS11090 2094197..2094970 - 774 WP_000750406.1 staphylococcal enterotoxin type A -
CNH35_RS11100 2095391..2095765 - 375 WP_000340977.1 hypothetical protein -
CNH35_RS11105 2095821..2096108 - 288 WP_001040259.1 hypothetical protein -
CNH35_RS11110 2096155..2096307 - 153 WP_001153681.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / chp / sak / sea / hlb / groEL 2089433..2146383 56950


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T81170 WP_011447039.1 NZ_CP023390:c2094088-2093912 [Staphylococcus aureus subsp. aureus str. Newman]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T81170 NZ_CP023390:c2094088-2093912 [Staphylococcus aureus subsp. aureus str. Newman]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 56 bp

>AT81170 NZ_CP023390:2093789-2093844 [Staphylococcus aureus subsp. aureus str. Newman]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References