Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 942916..943223 Replicon chromosome
Accession NZ_CP077860
Organism Staphylococcus aureus strain AC4

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag KU521_RS04670 Protein ID WP_011447039.1
Coordinates 943047..943223 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 942916..943055 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU521_RS04630 (938254) 938254..938514 + 261 WP_001791826.1 hypothetical protein -
KU521_RS04635 (938567) 938567..938917 - 351 WP_000702263.1 complement inhibitor SCIN-A -
KU521_RS04640 (939603) 939603..940052 + 450 WP_000727649.1 chemotaxis-inhibiting protein CHIPS -
KU521_RS04645 (940147) 940147..940482 - 336 Protein_887 SH3 domain-containing protein -
KU521_RS04650 (941132) 941132..941623 - 492 WP_000919350.1 staphylokinase -
KU521_RS04655 (941814) 941814..942569 - 756 WP_000861038.1 CHAP domain-containing protein -
KU521_RS04660 (942581) 942581..942835 - 255 WP_000611512.1 phage holin -
KU521_RS04665 (942887) 942887..942994 + 108 WP_001791821.1 hypothetical protein -
- (942916) 942916..943055 + 140 NuclAT_0 - Antitoxin
- (942916) 942916..943055 + 140 NuclAT_0 - Antitoxin
- (942916) 942916..943055 + 140 NuclAT_0 - Antitoxin
- (942916) 942916..943055 + 140 NuclAT_0 - Antitoxin
KU521_RS04670 (943047) 943047..943223 - 177 WP_011447039.1 type I toxin-antitoxin system toxin PepG1 Toxin
KU521_RS04675 (943332) 943332..944105 - 774 WP_000750406.1 staphylococcal enterotoxin type A -
KU521_RS04680 (944526) 944526..944900 - 375 WP_000340977.1 hypothetical protein -
KU521_RS04685 (944956) 944956..945243 - 288 WP_001040259.1 hypothetical protein -
KU521_RS04690 (945290) 945290..945442 - 153 WP_001153681.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / chp / sak / sea / hlb / groEL 938567..993424 54857


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T208222 WP_011447039.1 NZ_CP077860:c943223-943047 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T208222 NZ_CP103593:129349-129729 [Escherichia coli O25b:H4-ST131]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGCAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin


Download         Length: 140 bp

>AT208222 NZ_CP077860:942916-943055 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References