Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 92095..92402 Replicon chromosome
Accession NZ_CP077852
Organism Staphylococcus aureus strain N6

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag KU516_RS00510 Protein ID WP_011447039.1
Coordinates 92226..92402 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 92095..92234 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU516_RS00470 (87433) 87433..87693 + 261 WP_001791826.1 hypothetical protein -
KU516_RS00475 (87746) 87746..88096 - 351 WP_000702263.1 complement inhibitor SCIN-A -
KU516_RS00480 (88782) 88782..89231 + 450 WP_000727649.1 chemotaxis-inhibiting protein CHIPS -
KU516_RS00485 (89326) 89326..89661 - 336 Protein_93 SH3 domain-containing protein -
KU516_RS00490 (90311) 90311..90802 - 492 WP_000919350.1 staphylokinase -
KU516_RS00495 (90993) 90993..91748 - 756 WP_000861038.1 CHAP domain-containing protein -
KU516_RS00500 (91760) 91760..92014 - 255 WP_000611512.1 phage holin -
KU516_RS00505 (92066) 92066..92173 + 108 WP_001791821.1 hypothetical protein -
- (92095) 92095..92234 + 140 NuclAT_0 - Antitoxin
- (92095) 92095..92234 + 140 NuclAT_0 - Antitoxin
- (92095) 92095..92234 + 140 NuclAT_0 - Antitoxin
- (92095) 92095..92234 + 140 NuclAT_0 - Antitoxin
KU516_RS00510 (92226) 92226..92402 - 177 WP_011447039.1 type I toxin-antitoxin system toxin PepG1 Toxin
KU516_RS00515 (92511) 92511..93284 - 774 WP_000750406.1 staphylococcal enterotoxin type A -
KU516_RS00520 (93705) 93705..94079 - 375 WP_000340977.1 hypothetical protein -
KU516_RS00525 (94135) 94135..94422 - 288 WP_001040259.1 hypothetical protein -
KU516_RS00530 (94469) 94469..94621 - 153 WP_001153681.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - map / hlb / scn / chp / sak / sea / hlb / groEL 82735..139578 56843


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T208080 WP_011447039.1 NZ_CP077852:c92402-92226 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T208080 NZ_CP077852:c92402-92226 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 140 bp

>AT208080 NZ_CP077852:92095-92234 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References