208180

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2655287..2655710 Replicon chromosome
Accession NZ_CP077857
Organism Staphylococcus aureus strain L4

Toxin (Protein)


Gene name higB Uniprot ID A0A5S9I4Y6
Locus tag KU533_RS13110 Protein ID WP_001065091.1
Coordinates 2655287..2655538 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0E0VQM8
Locus tag KU533_RS13115 Protein ID WP_000028422.1
Coordinates 2655528..2655710 (+) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU533_RS13065 (2650942) 2650942..2651862 + 921 WP_000138472.1 recombinase RecT -
KU533_RS13070 (2651943) 2651943..2652560 + 618 WP_071621397.1 MBL fold metallo-hydrolase -
KU533_RS13075 (2652561) 2652561..2653031 + 471 WP_000934764.1 single-stranded DNA-binding protein -
KU533_RS13080 (2653061) 2653061..2653945 + 885 WP_000148316.1 DnaD domain protein -
KU533_RS13085 (2653952) 2653952..2654170 + 219 WP_000338531.1 hypothetical protein -
KU533_RS13090 (2654179) 2654179..2654488 + 310 Protein_2537 RusA family crossover junction endodeoxyribonuclease -
KU533_RS13095 (2654501) 2654501..2654869 + 369 WP_000101274.1 SA1788 family PVL leukocidin-associated protein -
KU533_RS13100 (2654873) 2654873..2655115 + 243 WP_000131366.1 SAV1978 family virulence-associated passenger protein -
KU533_RS13105 (2655127) 2655127..2655294 + 168 WP_001624242.1 hypothetical protein -
KU533_RS13110 (2655287) 2655287..2655538 + 252 WP_001065091.1 DUF1024 family protein Toxin
KU533_RS13115 (2655528) 2655528..2655710 + 183 WP_000028422.1 hypothetical protein Antitoxin
KU533_RS13120 (2655703) 2655703..2656245 + 543 WP_000185659.1 dUTP pyrophosphatase -
KU533_RS13125 (2656282) 2656282..2656488 + 207 WP_000195803.1 DUF1381 domain-containing protein -
KU533_RS13130 (2656485) 2656485..2656871 + 387 WP_000592207.1 hypothetical protein -
KU533_RS13135 (2656868) 2656868..2657017 + 150 WP_000595265.1 transcriptional activator RinB -
KU533_RS13140 (2657017) 2657017..2657217 + 201 WP_000265043.1 DUF1514 family protein -
KU533_RS13145 (2657245) 2657245..2657661 + 417 WP_000590122.1 hypothetical protein -
KU533_RS13150 (2657893) 2657893..2658192 + 300 WP_000988336.1 HNH endonuclease -
KU533_RS13155 (2658322) 2658322..2658666 + 345 WP_000402904.1 hypothetical protein -
KU533_RS13160 (2658663) 2658663..2660324 + 1662 WP_000625088.1 terminase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - hlb / sea / sak / chp / scn / hlb / map 2635813..2688389 52576


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9349.22 Da        Isoelectric Point: 3.9473

>T208180 WP_001065091.1 NZ_CP077857:2655287-2655538 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEH

Download         Length: 252 bp

>T208180 NZ_CP077857:2655287-2655538 [Staphylococcus aureus]
ATGAATAATCGCGAACAAATTGAACAATCAGTTATAAGTGCTAGTGCGTATAACGGTAATGACACAGAGGGATTACTAAA
AGAGATTGAGGACGTTTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAACATTCAG
TTAAAGAAGGTGTTGAACTTGATGAAGCAGTAGGGATTATGGCAGGTCAAGTTGTCTATAAATATGAGGAGGAACAGGAA
AATGAGCATTAG

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6741.63 Da        Isoelectric Point: 4.2658

>AT208180 WP_000028422.1 NZ_CP077857:2655528-2655710 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEEQEND

Download         Length: 183 bp

>AT208180 NZ_CP077857:2655528-2655710 [Staphylococcus aureus]
ATGAGCATTAGTGTAGGAGACAAGGTTTTTAATCCAGAAACAAATTCAACTTTAGAAATTGTACAACTTGTTGGCGATAT
TAGAGACACGCATTACAAGTTATCTGACGGATCTATTATTAGTCTTATAGACTTTGTTGTTAAACCAATTCATTTAATCA
AGGAGGAGCAGGAAAATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5S9I4Y6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VQM8

References