Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 2409719..2410026 Replicon chromosome
Accession NZ_CP060278
Organism Staphylococcus aureus strain KZN

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag H7684_RS11760 Protein ID WP_011447039.1
Coordinates 2409850..2410026 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 2409719..2409858 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7684_RS11720 (2405057) 2405057..2405317 + 261 WP_001791826.1 hypothetical protein -
H7684_RS11725 (2405370) 2405370..2405720 - 351 WP_000702263.1 complement inhibitor SCIN-A -
H7684_RS11730 (2406406) 2406406..2406855 + 450 WP_000727649.1 chemotaxis-inhibiting protein CHIPS -
H7684_RS11735 (2406950) 2406950..2407285 - 336 Protein_2287 SH3 domain-containing protein -
H7684_RS11740 (2407935) 2407935..2408426 - 492 WP_000919350.1 staphylokinase -
H7684_RS11745 (2408617) 2408617..2409372 - 756 WP_000861038.1 CHAP domain-containing protein -
H7684_RS11750 (2409384) 2409384..2409638 - 255 WP_000611512.1 phage holin -
H7684_RS11755 (2409690) 2409690..2409797 + 108 WP_001791821.1 hypothetical protein -
- (2409719) 2409719..2409858 + 140 NuclAT_0 - Antitoxin
- (2409719) 2409719..2409858 + 140 NuclAT_0 - Antitoxin
- (2409719) 2409719..2409858 + 140 NuclAT_0 - Antitoxin
- (2409719) 2409719..2409858 + 140 NuclAT_0 - Antitoxin
H7684_RS11760 (2409850) 2409850..2410026 - 177 WP_011447039.1 type I toxin-antitoxin system toxin PepG1 Toxin
H7684_RS11765 (2410135) 2410135..2410908 - 774 WP_000750406.1 staphylococcal enterotoxin type A -
H7684_RS11770 (2411329) 2411329..2411703 - 375 WP_000340977.1 hypothetical protein -
H7684_RS11775 (2411759) 2411759..2412046 - 288 WP_001040259.1 hypothetical protein -
H7684_RS11780 (2412093) 2412093..2412245 - 153 WP_001153681.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / chp / sak / sea / hlb / groEL 2405370..2457201 51831


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T170201 WP_011447039.1 NZ_CP060278:c2410026-2409850 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T170201 NZ_CP077198:c552604-552107 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCCCTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATTGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGCGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 140 bp

>AT170201 NZ_CP060278:2409719-2409858 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References