Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2638408..2638831 Replicon chromosome
Accession NZ_CP077859
Organism Staphylococcus aureus strain AC5

Toxin (Protein)


Gene name higB Uniprot ID A0A5S9I4Y6
Locus tag KU537_RS12910 Protein ID WP_001065091.1
Coordinates 2638408..2638659 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0E0VQM8
Locus tag KU537_RS12915 Protein ID WP_000028422.1
Coordinates 2638649..2638831 (+) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU537_RS12865 (2634063) 2634063..2634983 + 921 WP_000138472.1 recombinase RecT -
KU537_RS12870 (2635064) 2635064..2635681 + 618 WP_071621397.1 MBL fold metallo-hydrolase -
KU537_RS12875 (2635682) 2635682..2636152 + 471 WP_000934764.1 single-stranded DNA-binding protein -
KU537_RS12880 (2636182) 2636182..2637066 + 885 WP_000148316.1 DnaD domain protein -
KU537_RS12885 (2637073) 2637073..2637291 + 219 WP_000338531.1 hypothetical protein -
KU537_RS12890 (2637300) 2637300..2637609 + 310 Protein_2528 RusA family crossover junction endodeoxyribonuclease -
KU537_RS12895 (2637622) 2637622..2637990 + 369 WP_000101274.1 SA1788 family PVL leukocidin-associated protein -
KU537_RS12900 (2637994) 2637994..2638236 + 243 WP_000131366.1 SAV1978 family virulence-associated passenger protein -
KU537_RS12905 (2638248) 2638248..2638415 + 168 WP_001624242.1 hypothetical protein -
KU537_RS12910 (2638408) 2638408..2638659 + 252 WP_001065091.1 DUF1024 family protein Toxin
KU537_RS12915 (2638649) 2638649..2638831 + 183 WP_000028422.1 hypothetical protein Antitoxin
KU537_RS12920 (2638824) 2638824..2639366 + 543 WP_000185659.1 dUTP pyrophosphatase -
KU537_RS12925 (2639403) 2639403..2639609 + 207 WP_000195803.1 DUF1381 domain-containing protein -
KU537_RS12930 (2639606) 2639606..2639992 + 387 WP_000592207.1 hypothetical protein -
KU537_RS12935 (2639989) 2639989..2640138 + 150 WP_000595265.1 transcriptional activator RinB -
KU537_RS12940 (2640138) 2640138..2640338 + 201 WP_000265043.1 DUF1514 family protein -
KU537_RS12945 (2640366) 2640366..2640782 + 417 WP_000590122.1 hypothetical protein -
KU537_RS12950 (2641014) 2641014..2641313 + 300 WP_000988336.1 HNH endonuclease -
KU537_RS12955 (2641443) 2641443..2641787 + 345 WP_000402904.1 hypothetical protein -
KU537_RS12960 (2641784) 2641784..2643445 + 1662 WP_000625088.1 terminase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - groEL / hlb / sea / sak / chp / scn / hlb / map 2614667..2671510 56843


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9349.22 Da        Isoelectric Point: 3.9473

>T208215 WP_001065091.1 NZ_CP077859:2638408-2638659 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEH

Download         Length: 252 bp

>T208215 NZ_CP103592:c4271001-4270714 [Escherichia coli O25b:H4-ST131]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTAGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCATAGAAAACGGTGAGTATCGCTGGCAGACTATCGGCC
TGGTTCACGGTATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAGCCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6741.63 Da        Isoelectric Point: 4.2658

>AT208215 WP_000028422.1 NZ_CP077859:2638649-2638831 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEEQEND

Download         Length: 183 bp

>AT208215 NZ_CP103592:c4270727-4270425 [Escherichia coli O25b:H4-ST131]
ATGAGCATGGTTAAACATAAACGAGGGACACCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCACTGGCGAA
TAAATTCGACGAAGATATTGATTACAGTGATATCCCGCCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACCCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGCTGAAGCGACCTGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5S9I4Y6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VQM8

References