Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 966235..966658 Replicon chromosome
Accession NZ_CP077860
Organism Staphylococcus aureus strain AC4

Toxin (Protein)


Gene name higB Uniprot ID A0A5S9I4Y6
Locus tag KU521_RS04815 Protein ID WP_001065091.1
Coordinates 966407..966658 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0E0VQM8
Locus tag KU521_RS04810 Protein ID WP_000028422.1
Coordinates 966235..966417 (-) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU521_RS04765 (961621) 961621..963282 - 1662 WP_000625088.1 terminase large subunit -
KU521_RS04770 (963279) 963279..963623 - 345 WP_000402904.1 hypothetical protein -
KU521_RS04775 (963753) 963753..964052 - 300 WP_000988336.1 HNH endonuclease -
KU521_RS04780 (964284) 964284..964700 - 417 WP_000590122.1 hypothetical protein -
KU521_RS04785 (964728) 964728..964928 - 201 WP_000265043.1 DUF1514 family protein -
KU521_RS04790 (964928) 964928..965077 - 150 WP_000595265.1 transcriptional activator RinB -
KU521_RS04795 (965074) 965074..965460 - 387 WP_000592207.1 hypothetical protein -
KU521_RS04800 (965457) 965457..965663 - 207 WP_000195803.1 DUF1381 domain-containing protein -
KU521_RS04805 (965700) 965700..966242 - 543 WP_000185659.1 dUTP pyrophosphatase -
KU521_RS04810 (966235) 966235..966417 - 183 WP_000028422.1 hypothetical protein Antitoxin
KU521_RS04815 (966407) 966407..966658 - 252 WP_001065091.1 DUF1024 family protein Toxin
KU521_RS04820 (966651) 966651..966818 - 168 WP_001624242.1 hypothetical protein -
KU521_RS04825 (966830) 966830..967072 - 243 WP_000131366.1 SAV1978 family virulence-associated passenger protein -
KU521_RS04830 (967076) 967076..967444 - 369 WP_000101274.1 SA1788 family PVL leukocidin-associated protein -
KU521_RS04835 (967457) 967457..967766 - 310 Protein_926 RusA family crossover junction endodeoxyribonuclease -
KU521_RS04840 (967775) 967775..967993 - 219 WP_000338531.1 hypothetical protein -
KU521_RS04845 (968000) 968000..968884 - 885 WP_000148316.1 DnaD domain protein -
KU521_RS04850 (968914) 968914..969384 - 471 WP_000934764.1 single-stranded DNA-binding protein -
KU521_RS04855 (969385) 969385..970002 - 618 WP_071621397.1 MBL fold metallo-hydrolase -
KU521_RS04860 (970083) 970083..971003 - 921 WP_000138472.1 recombinase RecT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / chp / sak / sea / hlb / groEL 938567..993424 54857


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9349.22 Da        Isoelectric Point: 3.9473

>T208225 WP_001065091.1 NZ_CP077860:c966658-966407 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEH

Download         Length: 252 bp

>T208225 NZ_CP103596:863154-863561 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6741.63 Da        Isoelectric Point: 4.2658

>AT208225 WP_000028422.1 NZ_CP077860:c966417-966235 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEEQEND

Download         Length: 183 bp

>AT208225 NZ_CP103596:862907-863173 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5S9I4Y6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VQM8

References